{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kusakisako K"],"funding":["Takeda Science Foundation","Japan Society for the Promotion of Science"],"pagination":["7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6997474"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Ticks are hematophagous arthropods, and their blood feeding on vertebrate hosts is essential for their development. The vertebrate blood contains high levels of free iron that can react with oxygen in ticks, resulting in the production of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), one of the reactive oxygen species. Peroxiredoxins (Prxs), H<sub>2</sub>O<sub>2</sub>-scavenging enzymes, take on an important role in the ticks' oxidative stress coping mechanism. Ticks also transmit several disease-causing pathogens, including tick-borne encephalitis virus (TBEV), in animals and humans. Therefore, the control of ticks and tick-borne pathogens is a key issue that needs to be addressed. Infection with an arthropod-borne flavivirus is known to induce oxidative stress in insect cells. We hypot"],"journal":["Frontiers in cellular and infection microbiology"],"pubmed_title":["A Peroxiredoxin From the <i>Haemaphysalis longicornis</i> Tick Affects Langat Virus Replication in a Hamster Cell Line."],"pmcid":["PMC6997474"],"funding_grant_id":["17K19328","17H03910","16H05028","16J08221"],"pubmed_authors":["Hernandez EP","Morokuma H","Yoshii K","Tanaka T","Kusakisako K","Talactac MR"],"additional_accession":[]},"is_claimable":false,"name":"A Peroxiredoxin From the <i>Haemaphysalis longicornis</i> Tick Affects Langat Virus Replication in a Hamster Cell Line.","description":"Ticks are hematophagous arthropods, and their blood feeding on vertebrate hosts is essential for their development. The vertebrate blood contains high levels of free iron that can react with oxygen in ticks, resulting in the production of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), one of the reactive oxygen species. Peroxiredoxins (Prxs), H<sub>2</sub>O<sub>2</sub>-scavenging enzymes, take on an important role in the ticks' oxidative stress coping mechanism. Ticks also transmit several disease-causing pathogens, including tick-borne encephalitis virus (TBEV), in animals and humans. Therefore, the control of ticks and tick-borne pathogens is a key issue that needs to be addressed. Infection with an arthropod-borne flavivirus is known to induce oxidative stress in insect cells. We hypot","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-26T18:23:50.05Z","creation":"2020-05-22T10:02:53Z"},"accession":"S-EPMC6997474","cross_references":{"pubmed":["32047725"],"doi":["10.3389/fcimb.2020.00007"]}}