{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nelson AJ"],"funding":["BLRD VA","NICHD NIH HHS","the King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia (A.A.); Veterans Administration","NIDDK NIH HHS","Iacocca Family Foundation","NIAID NIH HHS","NHLBI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["143-158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6997598"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(2)"],"pubmed_abstract":["Phospholipases A<sub>2</sub> (PLA<sub>2</sub>s) catalyze hydrolysis of the <i>sn</i>-2 substituent from glycerophospholipids to yield a free fatty acid (i.e., arachidonic acid), which can be metabolized to pro- or anti-inflammatory eicosanoids. Macrophages modulate inflammatory responses and are affected by Ca<sup>2+</sup>-independent phospholipase A<sub>2</sub> (PLA<sub>2</sub>)β (iPLA<sub>2</sub>β). Here, we assessed the link between iPLA<sub>2</sub>β-derived lipids (iDLs) and macrophage polarization. Macrophages from WT and KO (<i>iPLA<sub>2</sub>β-/-</i>) mice were classically M1 pro-inflammatory phenotype activated or alternatively M2 anti-inflammatory phenotype activated, and eicosanoid production was determined by ultra-performance LC ESI-MS/MS. As a genotypic control, we performed "],"journal":["Journal of lipid research"],"pubmed_title":["Macrophage polarization is linked to Ca<sup>2+</sup>-independent phospholipase A<sub>2</sub>β-derived lipids and cross-cell signaling in mice."],"pmcid":["PMC6997598"],"funding_grant_id":["R01 DK069455","R01 DK69455","R01 DK110292","RR031535","R01 HL125353","P30 DK079626","T32 GM008111","R01 AI139072","I01 BX001792","U01 HD087198","IK6 BX004603"],"pubmed_authors":["Nelson AJ","Barbour SE","Ramanadham S","Chalfant CE","Lei X","Cardona CL","Stephenson DJ","Tusing YG","Park MA","White TD","Almutairi A"],"additional_accession":[]},"is_claimable":false,"name":"Macrophage polarization is linked to Ca<sup>2+</sup>-independent phospholipase A<sub>2</sub>β-derived lipids and cross-cell signaling in mice.","description":"Phospholipases A<sub>2</sub> (PLA<sub>2</sub>s) catalyze hydrolysis of the <i>sn</i>-2 substituent from glycerophospholipids to yield a free fatty acid (i.e., arachidonic acid), which can be metabolized to pro- or anti-inflammatory eicosanoids. Macrophages modulate inflammatory responses and are affected by Ca<sup>2+</sup>-independent phospholipase A<sub>2</sub> (PLA<sub>2</sub>)β (iPLA<sub>2</sub>β). Here, we assessed the link between iPLA<sub>2</sub>β-derived lipids (iDLs) and macrophage polarization. Macrophages from WT and KO (<i>iPLA<sub>2</sub>β-/-</i>) mice were classically M1 pro-inflammatory phenotype activated or alternatively M2 anti-inflammatory phenotype activated, and eicosanoid production was determined by ultra-performance LC ESI-MS/MS. As a genotypic control, we performed ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-04-22T09:35:05.727Z","creation":"2021-02-21T04:28:20Z"},"accession":"S-EPMC6997598","cross_references":{"pubmed":["31818877"],"doi":["10.1194/jlr.RA119000281","10.1194/jlr.ra119000281"]}}