{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee Q"],"funding":["NIAID NIH HHS","NCI NIH HHS"],"pagination":["e1008262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6999912"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify \"p10\" and \"p15\" as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropi"],"journal":["PLoS pathogens"],"pubmed_title":["Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys."],"pmcid":["PMC6999912"],"funding_grant_id":["P30 CA008748","U19 AI109761"],"pubmed_authors":["Lee Q","Brenner O","Pinello N","Padula MP","Shaban B","Monette S","Crim MJ","Roediger B","Wong JJ","O'Rourke MB","Jolly CJ","Weninger W","Song R","Souza WM","Pimanda JE","Williams SH","Fumagalli MJ","Orkin JD","Melin AD"],"additional_accession":[]},"is_claimable":false,"name":"Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys.","description":"Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify \"p10\" and \"p15\" as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropi","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2026-05-07T00:38:07.089Z","creation":"2020-05-22T10:32:32Z"},"accession":"S-EPMC6999912","cross_references":{"pubmed":["31971979"],"doi":["10.1371/journal.ppat.1008262"]}}