{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Egorova A"],"funding":["NCATS","NCATS NIH HHS","NIH"],"pagination":["112007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7002245"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["188"],"pubmed_abstract":["Today, there are no medicines to treat enterovirus and rhinovirus infections. In the present study, a series of novel pleconaril derivatives with substitutions in the isoxazole and phenyl rings was synthesized and evaluated for their antiviral activity against a panel of pleconaril-sensitive and -resistant enteroviruses. Studies of the structure-activity relationship demonstrate the crucial role of the N,N-dimethylcarbamoyl group in the isoxazole ring for antiviral activity against pleconaril-resistant viruses. In addition, one or two substituents in the phenyl ring directly impact on the spectrum of antienteroviral activity. The 3-(3-methyl-4-(3-(3-N,N-dimethylcarbamoyl-isoxazol-5-yl)propoxy)phenyl)-5-trifluoromethyl-1,2,4-oxadiazole 10g was among the compounds exhibiting the strongest ac"],"journal":["European journal of medicinal chemistry"],"pubmed_title":["Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses."],"pmcid":["PMC7002245"],"funding_grant_id":["R21TR001718","R21 TR001718"],"pubmed_authors":["Jahn B","Ekins S","Kazakova E","Makarov V","Schmidtke M","Egorova A"],"additional_accession":[]},"is_claimable":false,"name":"Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses.","description":"Today, there are no medicines to treat enterovirus and rhinovirus infections. In the present study, a series of novel pleconaril derivatives with substitutions in the isoxazole and phenyl rings was synthesized and evaluated for their antiviral activity against a panel of pleconaril-sensitive and -resistant enteroviruses. Studies of the structure-activity relationship demonstrate the crucial role of the N,N-dimethylcarbamoyl group in the isoxazole ring for antiviral activity against pleconaril-resistant viruses. In addition, one or two substituents in the phenyl ring directly impact on the spectrum of antienteroviral activity. The 3-(3-methyl-4-(3-(3-N,N-dimethylcarbamoyl-isoxazol-5-yl)propoxy)phenyl)-5-trifluoromethyl-1,2,4-oxadiazole 10g was among the compounds exhibiting the strongest ac","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-04-19T02:20:41.802Z","creation":"2021-02-21T09:33:42Z"},"accession":"S-EPMC7002245","cross_references":{"pubmed":["31881489"],"doi":["10.1016/j.ejmech.2019.112007"]}}