{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Naidu SK"],"funding":["Louisiana Board of Regents","NIGMS NIH HHS"],"pagination":["e0228252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7004361"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["Herpes simplex virus type-1 (HSV-1) can cause severe ocular infection and blindness. We have previously shown that the HSV-1 VC2 vaccine strain is protective in mice and guinea pigs against genital herpes infection following vaginal challenge with HSV-1 or HSV-2. In this study, we evaluated the efficacy of VC2 intramuscular vaccination in mice against herpetic keratitis following ocular challenge with lethal human clinical strain HSV-1(McKrae). VC2 vaccination in mice produced superior protection and morbidity control in comparison to its parental strain HSV-1(F). Specifically, after HSV-1(McKrae) ocular challenge, all VC2 vaccinated- mice survived, while 30% of the HSV-1(F)- vaccinated and 100% of the mock-vaccinated mice died post challenge. VC2-vaccinated mice did not exhibit any sympto"],"journal":["PloS one"],"pubmed_title":["Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis."],"pmcid":["PMC7004361"],"funding_grant_id":["P20 GM103424","GBI"],"pubmed_authors":["Kousoulas KG","Jambunathan N","Nabi R","Langohr I","Cheemarla NR","Rider PJ","Stanfield BA","Naidu SK","Carter R","Del Piero F","Chouljenko VN"],"additional_accession":[]},"is_claimable":false,"name":"Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis.","description":"Herpes simplex virus type-1 (HSV-1) can cause severe ocular infection and blindness. We have previously shown that the HSV-1 VC2 vaccine strain is protective in mice and guinea pigs against genital herpes infection following vaginal challenge with HSV-1 or HSV-2. In this study, we evaluated the efficacy of VC2 intramuscular vaccination in mice against herpetic keratitis following ocular challenge with lethal human clinical strain HSV-1(McKrae). VC2 vaccination in mice produced superior protection and morbidity control in comparison to its parental strain HSV-1(F). Specifically, after HSV-1(McKrae) ocular challenge, all VC2 vaccinated- mice survived, while 30% of the HSV-1(F)- vaccinated and 100% of the mock-vaccinated mice died post challenge. VC2-vaccinated mice did not exhibit any sympto","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-19T01:59:05.709Z","creation":"2020-05-22T10:27:21Z"},"accession":"S-EPMC7004361","cross_references":{"pubmed":["32027675"],"doi":["10.1371/journal.pone.0228252"]}}