{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Cantoro L"],"pubmed_abstract":["<h4>Background</h4>Disease heterogeneity, according to the age at onset, has been reported in Crohn's disease (CD).<h4>Objective</h4>This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old.<h4>Methods</h4>EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra-intestinal manifestations and use of medical/surgical therapy during the follow-up period.<h4>Results</h4>Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow-up 11.7 ± 7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; <"],"journal":["United European gastroenterology journal"],"pagination":["52-58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7006006"],"repository":["biostudies-literature"],"pubmed_title":["Early-onset versus late-onset Crohn's disease: An Italian cohort study."],"pmcid":["PMC7006006"],"pubmed_authors":["Cicala M","Giannarelli D","Papi C","Kohn A","Di Sabatino A","Monterubbianesi R","Cantoro L","Lenti MV"],"additional_accession":[]},"is_claimable":false,"name":"Early-onset versus late-onset Crohn's disease: An Italian cohort study.","description":"<h4>Background</h4>Disease heterogeneity, according to the age at onset, has been reported in Crohn's disease (CD).<h4>Objective</h4>This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old.<h4>Methods</h4>EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra-intestinal manifestations and use of medical/surgical therapy during the follow-up period.<h4>Results</h4>Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow-up 11.7 ± 7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; <","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-04-22T00:19:49.84Z","creation":"2025-04-05T19:28:34.677Z"},"accession":"S-EPMC7006006","cross_references":{"pubmed":["32213053"],"doi":["10.1177/2050640619860661"]}}