biostudies-literatureUnknown8(1)Cantoro L<h4>Background</h4>Disease heterogeneity, according to the age at onset, has been reported in Crohn's disease (CD).<h4>Objective</h4>This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old.<h4>Methods</h4>EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra-intestinal manifestations and use of medical/surgical therapy during the follow-up period.<h4>Results</h4>Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow-up 11.7 ± 7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; <United European gastroenterology journal52-58https://www.ebi.ac.uk/biostudies/studies/S-EPMC7006006biostudies-literatureEarly-onset versus late-onset Crohn's disease: An Italian cohort study.PMC7006006Cicala MGiannarelli DPapi CKohn ADi Sabatino AMonterubbianesi RCantoro LLenti MVfalseEarly-onset versus late-onset Crohn's disease: An Italian cohort study.<h4>Background</h4>Disease heterogeneity, according to the age at onset, has been reported in Crohn's disease (CD).<h4>Objective</h4>This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old.<h4>Methods</h4>EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra-intestinal manifestations and use of medical/surgical therapy during the follow-up period.<h4>Results</h4>Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow-up 11.7 ± 7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; <2020-01-01T00:00:00Z2020 Feb2025-04-22T00:19:49.84Z2025-04-05T19:28:34.677ZS-EPMC70060063221305310.1177/2050640619860661