{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":56,"searchCount":0},"additional":{"submitter":["Vlasova KY"],"funding":["Alliance for Nanotechnology in Cancer","Eshelman Institute for Innovation","National Cancer Institute","NCI NIH HHS","Russian Foundation for Basic Research"],"pagination":["689-700"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7012191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["552"],"pubmed_abstract":["<h4>Hypothesis</h4>Magnetic liposomes are shown to release the entrapped dye once modulated by low frequency AC MF. The mechanism and effectiveness of MF application should depend on lipid composition, magnetic nanoparticles (MNPs) properties, temperature and field parameters.<h4>Experiments</h4>The study was performed using liposomes of various lipid composition and embedded hydrophobic MNPs. The liposomes structural changes were studied by the transmission electron microscopy (TEM) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and the leakage was monitored by the fluorescent dye release.<h4>Findings</h4>Magnetic liposomes exposure to the AC MF resulted in the clustering of the MNPs in the membranes and disruption of the lipid packaging. Addition of cholesterol diminished the dye release from the saturated lipid-based liposomes. Replacement of the saturated lipid for unsaturated one also decreased the dye release. The dye release depended on the strength, but not the frequency of the field. Thus, the oscillating motion of MNPs in AC MF ruptures the gel phase membranes of saturated lipids. As the temperature increases the disruption also increases. In the liquid crystalline membranes formed by unsaturated lipids the deformations and defects created by mechanical motion of the MNPs are more likely to heal and results in decreased release."],"journal":["Journal of colloid and interface science"],"pubmed_title":["Magnetic liposome design for drug release systems responsive to super-low frequency alternating current magnetic field (AC MF)."],"pmcid":["PMC7012191"],"funding_grant_id":["18-29-09154","17-54-33027","R21 CA220148","U54 CA198999"],"pubmed_authors":["Vlasova KY","Klyachko NL","Le-Deygen IM","Golovin YI","Rudakovskaya PG","Kireev II","Piroyan A","Sokolsky-Papkov M","Vishwasrao HM","Ramsey JD","Kabanov AV"],"view_count":["56"],"additional_accession":[]},"is_claimable":false,"name":"Magnetic liposome design for drug release systems responsive to super-low frequency alternating current magnetic field (AC MF).","description":"<h4>Hypothesis</h4>Magnetic liposomes are shown to release the entrapped dye once modulated by low frequency AC MF. The mechanism and effectiveness of MF application should depend on lipid composition, magnetic nanoparticles (MNPs) properties, temperature and field parameters.<h4>Experiments</h4>The study was performed using liposomes of various lipid composition and embedded hydrophobic MNPs. The liposomes structural changes were studied by the transmission electron microscopy (TEM) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and the leakage was monitored by the fluorescent dye release.<h4>Findings</h4>Magnetic liposomes exposure to the AC MF resulted in the clustering of the MNPs in the membranes and disruption of the lipid packaging. Addition of cholesterol diminished the dye release from the saturated lipid-based liposomes. Replacement of the saturated lipid for unsaturated one also decreased the dye release. The dye release depended on the strength, but not the frequency of the field. Thus, the oscillating motion of MNPs in AC MF ruptures the gel phase membranes of saturated lipids. As the temperature increases the disruption also increases. In the liquid crystalline membranes formed by unsaturated lipids the deformations and defects created by mechanical motion of the MNPs are more likely to heal and results in decreased release.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2024-10-15T02:02:06.912Z","creation":"2020-09-17T07:03:38Z"},"accession":"S-EPMC7012191","cross_references":{"pubmed":["31176052"],"doi":["10.1016/j.jcis.2019.05.071"]}}