{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yaron JR"],"funding":["American Heart Association","University of Florida","NIAID NIH HHS","NHLBI NIH HHS","U.S. Department of Health &amp; Human Services | National Institutes of Health"],"pagination":["2371"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7012916"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Immunopathogenesis in systemic viral infections can induce a septic state with leaky capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment options. Murine gammaherpesvirus-68 (MHV-68) intraperitoneal infection is a gammaherpesvirus model for producing severe vasculitis, colitis and lethal hemorrhagic pneumonia in interferon gamma receptor-deficient (IFNγR<sup>-/-</sup>) mice. In prior work, treatment with myxomavirus-derived Serp-1 or a derivative peptide S-7 (G<sub>305</sub>TTASSDTAITLIPR<sub>319</sub>) induced immune protection, reduced disease severity and improved survival after MHV-68 infection. Here, we investigate the gut bacterial microbiome in MHV-68 infection. Antibiotic suppression markedly accelerated MHV-68 pathology causing pulmonary consoli"],"journal":["Scientific reports"],"pubmed_title":["Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection."],"pmcid":["PMC7012916"],"funding_grant_id":["1R01AI100987-01A1","RC1 HL100202","00115070","17GRNT33460327","R01 AI100987","1RC1HL100202"],"pubmed_authors":["Yaron JR","Tibbetts SA","Bullard WL","Koppang EO","Munk BH","Lucas AR","Keinan S","Zhang L","Maldonado J","Ambadapadi S","Varsani A","Tafoya AM","Stern-Harbutte A","Chavan RN","Krajmalnik-Brown R","Lim ES","Kraberger S","Kilbourne J"],"additional_accession":[]},"is_claimable":false,"name":"Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.","description":"Immunopathogenesis in systemic viral infections can induce a septic state with leaky capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment options. Murine gammaherpesvirus-68 (MHV-68) intraperitoneal infection is a gammaherpesvirus model for producing severe vasculitis, colitis and lethal hemorrhagic pneumonia in interferon gamma receptor-deficient (IFNγR<sup>-/-</sup>) mice. In prior work, treatment with myxomavirus-derived Serp-1 or a derivative peptide S-7 (G<sub>305</sub>TTASSDTAITLIPR<sub>319</sub>) induced immune protection, reduced disease severity and improved survival after MHV-68 infection. Here, we investigate the gut bacterial microbiome in MHV-68 infection. Antibiotic suppression markedly accelerated MHV-68 pathology causing pulmonary consoli","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2026-05-02T20:00:39.021Z","creation":"2020-05-22T10:40:50Z"},"accession":"S-EPMC7012916","cross_references":{"pubmed":["32047224"],"doi":["10.1038/s41598-020-59269-9"]}}