biostudies-literatureYaron JRAmerican Heart AssociationUniversity of FloridaNIAID NIH HHSNHLBI NIH HHSU.S. Department of Health & Human Services | National Institutes of Health2371https://www.ebi.ac.uk/biostudies/studies/S-EPMC7012916biostudies-literatureUnknown10(1)Immunopathogenesis in systemic viral infections can induce a septic state with leaky capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment options. Murine gammaherpesvirus-68 (MHV-68) intraperitoneal infection is a gammaherpesvirus model for producing severe vasculitis, colitis and lethal hemorrhagic pneumonia in interferon gamma receptor-deficient (IFNγR^-/-) mice. In prior work, treatment with myxomavirus-derived Serp-1 or a derivative peptide S-7 (G₃₀₅TTASSDTAITLIPR₃₁₉) induced immune protection, reduced disease severity and improved survival after MHV-68 infection. Here, we investigate the gut bacterial microbiome in MHV-68 infection. Antibiotic suppression markedly accelerated MHV-68 pathology causing pulmonary consoliScientific reportsImmune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.PMC70129161R01AI100987-01A1RC1 HL1002020011507017GRNT33460327R01 AI1009871RC1HL100202Yaron JRTibbetts SABullard WLKoppang EOMunk BHLucas ARKeinan SZhang LMaldonado JAmbadapadi SVarsani ATafoya AMStern-Harbutte AChavan RNKrajmalnik-Brown RLim ESKraberger SKilbourne JfalseImmune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.Immunopathogenesis in systemic viral infections can induce a septic state with leaky capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment options. Murine gammaherpesvirus-68 (MHV-68) intraperitoneal infection is a gammaherpesvirus model for producing severe vasculitis, colitis and lethal hemorrhagic pneumonia in interferon gamma receptor-deficient (IFNγR^-/-) mice. In prior work, treatment with myxomavirus-derived Serp-1 or a derivative peptide S-7 (G₃₀₅TTASSDTAITLIPR₃₁₉) induced immune protection, reduced disease severity and improved survival after MHV-68 infection. Here, we investigate the gut bacterial microbiome in MHV-68 infection. Antibiotic suppression markedly accelerated MHV-68 pathology causing pulmonary consoli2020-01-01T00:00:00Z2020 Feb2026-05-02T20:00:39.021Z2020-05-22T10:40:50ZS-EPMC70129163204722410.1038/s41598-020-59269-9