{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li F"],"funding":["Six Talent Peaks Project in Jiangsu Province"],"pagination":["1753466620905274"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7013116"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["<h4>Background</h4>Angiopoietin-2 (Ang-2), as one of the ligands of endothelial receptor Tie2, is known to be significant for vessel maturation and stabilization after birth. Previous studies showed the relationship between Ang-2 level and the risk of mortality in patients with acute respiratory distress syndrome (ARDS). However, the link between circulating Ang-2 and the risk of mortality in patients with ARDS varied in different investigations.<h4>Results</h4>We performed a systematic review and meta-analysis of all available cohort studies regarding the association between baseline circulating Ang-2 and mortality in patients with ARDS. Among the 10 eligible studies, pooled odds ratio (OR) showed that high Ang-2 level contributed to ARDS mortality [OR = 1.56, 95% confidence interval (CI)"],"journal":["Therapeutic advances in respiratory disease"],"pubmed_title":["Circulating angiopoietin-2 and the risk of mortality in patients with acute respiratory distress syndrome: a systematic review and meta-analysis of 10 prospective cohort studies."],"pmcid":["PMC7013116"],"funding_grant_id":["WSN021"],"pubmed_authors":["Li F","Yin R","Guo Q"],"additional_accession":[]},"is_claimable":false,"name":"Circulating angiopoietin-2 and the risk of mortality in patients with acute respiratory distress syndrome: a systematic review and meta-analysis of 10 prospective cohort studies.","description":"<h4>Background</h4>Angiopoietin-2 (Ang-2), as one of the ligands of endothelial receptor Tie2, is known to be significant for vessel maturation and stabilization after birth. Previous studies showed the relationship between Ang-2 level and the risk of mortality in patients with acute respiratory distress syndrome (ARDS). However, the link between circulating Ang-2 and the risk of mortality in patients with ARDS varied in different investigations.<h4>Results</h4>We performed a systematic review and meta-analysis of all available cohort studies regarding the association between baseline circulating Ang-2 and mortality in patients with ARDS. Among the 10 eligible studies, pooled odds ratio (OR) showed that high Ang-2 level contributed to ARDS mortality [OR = 1.56, 95% confidence interval (CI)","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan-Dec","modification":"2025-04-21T20:00:17.202Z","creation":"2020-05-22T10:51:17Z"},"accession":"S-EPMC7013116","cross_references":{"pubmed":["32043429"],"doi":["10.1177/1753466620905274"]}}