biostudies-literatureCaprio CAssociazione Italiana per la Ricerca sul CancroFondation LeducqRegione CampaniaE607https://www.ebi.ac.uk/biostudies/studies/S-EPMC7014135biostudies-literatureUnknown21(2)Early events of basal cell carcinoma (BCC) tumorigenesis are triggered by inappropriate activation of SHH signaling, via the loss of Patched1 (Ptch1) or by activating mutations of Smoothened (Smo). TBX1 is a key regulator of pharyngeal development, mainly through expression in multipotent progenitor cells of the cardiopharyngeal lineage. This transcription factor is connected to several major signaling systems, such as FGF, WNT, and SHH, and it has been linked to cell proliferation and to the regulation of cell shape and cell dynamics. Here, we show that TBX1 was expressed in all of the 51 BCC samples that we have tested, while in healthy human skin it was only expressed in the hair follicle. Signal intensity and distribution was heterogeneous among tumor samples. Experiments performed on International journal of molecular sciencesTBX1 and Basal Cell Carcinoma: Expression and Interactions with Gli2 and Dvl2 Signaling.PMC7014135IG-1752915CVD01IG-17079SATINRusso DVarricchio SIlardi GBilio MMissero CCaprio CBaldini AStaibano SFerrentino RAlfano DFeo FfalseTBX1 and Basal Cell Carcinoma: Expression and Interactions with Gli2 and Dvl2 Signaling.Early events of basal cell carcinoma (BCC) tumorigenesis are triggered by inappropriate activation of SHH signaling, via the loss of Patched1 (Ptch1) or by activating mutations of Smoothened (Smo). TBX1 is a key regulator of pharyngeal development, mainly through expression in multipotent progenitor cells of the cardiopharyngeal lineage. This transcription factor is connected to several major signaling systems, such as FGF, WNT, and SHH, and it has been linked to cell proliferation and to the regulation of cell shape and cell dynamics. Here, we show that TBX1 was expressed in all of the 51 BCC samples that we have tested, while in healthy human skin it was only expressed in the hair follicle. Signal intensity and distribution was heterogeneous among tumor samples. Experiments performed on 2020-01-01T00:00:00Z2020 Jan2025-04-21T13:57:40.565Z2020-05-22T12:18:20ZS-EPMC70141353196347410.3390/ijms21020607