biostudies-literatureHan KHNational Research Foundation of KoreaE256https://www.ebi.ac.uk/biostudies/studies/S-EPMC7017361biostudies-literatureUnknown9(1)We present data showing that Iodotyrosine Deiodinase (IYD) is a dual-function enzyme acting as a catalyst in metabolism and a receptor for cooperative stem cell differentiation. IYD is present both in thyroid cells where it is critical for scavenging iodine from halogenated by-products of thyroid hormone production and on hematopoietic stem cells. To close the cooperative loop, the mono- and di-Iodotyrosine (MIT and DIT) substrates of IYD in the thyroid are also agonists for IYD now acting as a receptor on bone marrow stem cells. While studying intracellular combinatorial antibody libraries, we discovered an agonist antibody, H3 Ab, of which the target is the enzyme IYD. When agonized by H3 Ab, IYD expressed on stem cells induces differentiation of the cells into brown adipocyte-like cellsCellsAgonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart.PMC70173612016R1A2B40063132019R1I1A1A01043181Lee SJin HYKang GHLin CWLee PCLerner RAArlian BMHan KHfalseAgonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart.We present data showing that Iodotyrosine Deiodinase (IYD) is a dual-function enzyme acting as a catalyst in metabolism and a receptor for cooperative stem cell differentiation. IYD is present both in thyroid cells where it is critical for scavenging iodine from halogenated by-products of thyroid hormone production and on hematopoietic stem cells. To close the cooperative loop, the mono- and di-Iodotyrosine (MIT and DIT) substrates of IYD in the thyroid are also agonists for IYD now acting as a receptor on bone marrow stem cells. While studying intracellular combinatorial antibody libraries, we discovered an agonist antibody, H3 Ab, of which the target is the enzyme IYD. When agonized by H3 Ab, IYD expressed on stem cells induces differentiation of the cells into brown adipocyte-like cells2020-01-01T00:00:00Z2020 Jan2025-05-18T12:57:13.2Z2020-05-22T11:19:01ZS-EPMC70173613196862310.3390/cells9010256