biostudies-literatureUnknown10(1)Sugimoto ASignaling lymphocytic activation molecule family member 8 (SLAMF8) / B-lymphocyte activator macrophage expressed/CD353 is a member of the CD2 family. SLAMF8 suppresses macrophage function but enhances the growth of neoplastic mast cells via SHP-2. In this study, we found that some anaplastic large cell lymphoma (ALCL) samples were immunohistochemically positive for SLAMF8. However, we found no significant differences between SLAMF8-positive and SLAMF8-negative ALCL samples with respect to age, gender, site, or prognosis. We also identified SLAMF8 expression in ALCL cell lines, Karpas299, and SU-DHL-1. SLAMF8 knockdown decreased the activation of SHP-2 and the growth of these cell lines, and increased the apoptosis of these cell lines. In addition, we observed the interaction between SLAMF8Scientific reports2505https://www.ebi.ac.uk/biostudies/studies/S-EPMC7018816biostudies-literatureSLAM family member 8 is expressed in and enhances the growth of anaplastic large cell lymphoma.PMC7018816Moriyoshi KKataoka TRKitamura KSaito NSugimoto AHirata MUeshima CTakaori-Kondo AIto HOtsuka YNishikori MTakei YHaga HfalseSLAM family member 8 is expressed in and enhances the growth of anaplastic large cell lymphoma.Signaling lymphocytic activation molecule family member 8 (SLAMF8) / B-lymphocyte activator macrophage expressed/CD353 is a member of the CD2 family. SLAMF8 suppresses macrophage function but enhances the growth of neoplastic mast cells via SHP-2. In this study, we found that some anaplastic large cell lymphoma (ALCL) samples were immunohistochemically positive for SLAMF8. However, we found no significant differences between SLAMF8-positive and SLAMF8-negative ALCL samples with respect to age, gender, site, or prognosis. We also identified SLAMF8 expression in ALCL cell lines, Karpas299, and SU-DHL-1. SLAMF8 knockdown decreased the activation of SHP-2 and the growth of these cell lines, and increased the apoptosis of these cell lines. In addition, we observed the interaction between SLAMF82020-01-01T00:00:00Z2020 Feb2025-04-25T21:07:34.06Z2020-05-22T10:42:50ZS-EPMC70188163205495410.1038/s41598-020-59530-1