{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Calvani R"],"funding":["Innovative Medicines Initiative","Seventh Framework Programme","Centro Studi Achille e Linda Lorenzon"],"pagination":["E199"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7019630"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of circulating 37 amino acids and derivatives between frail/pre-frail older adults with T2DM and robust non-diabetic controls. Sixty-six functionally impaired older persons aged 70+ with T2DM and 30 age and sex-matched controls were included in the analysis. We applied a partial least squares-discriminant analysis (PLS-DA)-based analytical strategy to characterize the metabotype of study participants. The optimal complexity of the PLS-DA model was found to be two latent variables. The proportion of c"],"journal":["Nutrients"],"pubmed_title":["Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study."],"pmcid":["PMC7019630"],"funding_grant_id":["N/A","115621","278803"],"pubmed_authors":["Gambassi G","Calvani R","Sinclair AJ","Laosa O","Primiano A","Rodriguez-Manas L","Picca A","Bernabei R","Marzetti E","Pedraza L","Gervasoni J","Regueme SC","Biancolillo A","Marini F","Conta G","Bourdel-Marchasson I"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study.","description":"Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of circulating 37 amino acids and derivatives between frail/pre-frail older adults with T2DM and robust non-diabetic controls. Sixty-six functionally impaired older persons aged 70+ with T2DM and 30 age and sex-matched controls were included in the analysis. We applied a partial least squares-discriminant analysis (PLS-DA)-based analytical strategy to characterize the metabotype of study participants. The optimal complexity of the PLS-DA model was found to be two latent variables. The proportion of c","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2026-05-02T23:00:19.047Z","creation":"2020-05-22T12:25:33Z"},"accession":"S-EPMC7019630","cross_references":{"pubmed":["31940925"],"doi":["10.3390/nu12010199"]}}