biostudies-literatureCalvani RInnovative Medicines InitiativeSeventh Framework ProgrammeCentro Studi Achille e Linda LorenzonE199https://www.ebi.ac.uk/biostudies/studies/S-EPMC7019630biostudies-literatureUnknown12(1)Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of circulating 37 amino acids and derivatives between frail/pre-frail older adults with T2DM and robust non-diabetic controls. Sixty-six functionally impaired older persons aged 70+ with T2DM and 30 age and sex-matched controls were included in the analysis. We applied a partial least squares-discriminant analysis (PLS-DA)-based analytical strategy to characterize the metabotype of study participants. The optimal complexity of the PLS-DA model was found to be two latent variables. The proportion of cNutrientsIdentification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study.PMC7019630N/A115621278803Gambassi GCalvani RSinclair AJLaosa OPrimiano ARodriguez-Manas LPicca ABernabei RMarzetti EPedraza LGervasoni JRegueme SCBiancolillo AMarini FConta GBourdel-Marchasson IfalseIdentification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study.Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of circulating 37 amino acids and derivatives between frail/pre-frail older adults with T2DM and robust non-diabetic controls. Sixty-six functionally impaired older persons aged 70+ with T2DM and 30 age and sex-matched controls were included in the analysis. We applied a partial least squares-discriminant analysis (PLS-DA)-based analytical strategy to characterize the metabotype of study participants. The optimal complexity of the PLS-DA model was found to be two latent variables. The proportion of c2020-01-01T00:00:00Z2020 Jan2026-05-02T23:00:19.047Z2020-05-22T12:25:33ZS-EPMC70196303194092510.3390/nu12010199