biostudies-literatureUnknown9(1)Lozano-Castellon J(1) Background: The health benefits of extra-virgin olive oil (EVOO), a key component of the Mediterranean diet, are attributed to its polyphenol profile. EVOO is often consumed cooked, and this process may degrade and transform polyphenols. (2) Methods: In this work, we determined how temperature, time, and the interaction between them affects the EVOO polyphenolic profile during a domestic pan-frying process, simulating the cooking conditions of a home kitchen, without the control of light or oxygen. Applying a 22 full factorial design experiment, "Hojiblanca" EVOO was processed at two temperatures (120 °C and 170 °C) either for a short time or a long time, mimicking a domestic process, and polyphenol content was analyzed by UPLC-ESI-QqQ-MS/MS. (3) Results: Temperature degraded the polypAntioxidants (Basel, Switzerland)E77https://www.ebi.ac.uk/biostudies/studies/S-EPMC7022658biostudies-literatureDomestic Sauteing with EVOO: Change in the Phenolic Profile.PMC7022658Lamuela-Raventos RMLozano-Castellon JIllan MTorrado-Prat XRinaldi de Alvarenga JFVallverdu-Queralt AfalseDomestic Sauteing with EVOO: Change in the Phenolic Profile.(1) Background: The health benefits of extra-virgin olive oil (EVOO), a key component of the Mediterranean diet, are attributed to its polyphenol profile. EVOO is often consumed cooked, and this process may degrade and transform polyphenols. (2) Methods: In this work, we determined how temperature, time, and the interaction between them affects the EVOO polyphenolic profile during a domestic pan-frying process, simulating the cooking conditions of a home kitchen, without the control of light or oxygen. Applying a 22 full factorial design experiment, "Hojiblanca" EVOO was processed at two temperatures (120 °C and 170 °C) either for a short time or a long time, mimicking a domestic process, and polyphenol content was analyzed by UPLC-ESI-QqQ-MS/MS. (3) Results: Temperature degraded the polyp2020-01-01T00:00:00Z2020 Jan2025-04-22T00:26:14.213Z2020-05-22T12:27:38ZS-EPMC70226583196312410.3390/antiox9010077