{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Khanal P"],"funding":["Erasmus Mundus, MOVE-AGE Joint Doctorate Scholarship"],"pubmed_abstract":["The prevalence of sarcopenia depends on the definition used. There are, however, consistent sarcopenic characteristics, including a low muscle mass and muscle strength. Few studies have investigated the relationship between sarcopenia and genotype. A cross-sectional study was conducted with 307 community-dwelling ≥60-year-old women in South Cheshire, UK. Handgrip strength was assessed with a handgrip dynamometer and skeletal muscle mass was estimated using bioelectrical impedance. DNA was extracted from saliva (∼38%) or blood (∼62%) and 24 single-nucleotide polymorphisms (SNPs) were genotyped. Three established sarcopenia definitions - %Skeletal Muscle Mass (%SMM), Skeletal Muscle Mass Index (SMI) and European Working Group on Sarcopenia in Older People (EWGSOP) - were used to assess sarco"],"journal":["Scientific reports"],"pagination":["2913"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7031370"],"repository":["biostudies-literature"],"pubmed_title":["Prevalence and association of single nucleotide polymorphisms with sarcopenia in older women depends on definition."],"pmcid":["PMC7031370"],"pubmed_authors":["Stebbings G","Khanal P","Degens H","He L","Onambele-Pearson GL","Williams A","Morse CI","Thomis M"],"additional_accession":[]},"is_claimable":false,"name":"Prevalence and association of single nucleotide polymorphisms with sarcopenia in older women depends on definition.","description":"The prevalence of sarcopenia depends on the definition used. There are, however, consistent sarcopenic characteristics, including a low muscle mass and muscle strength. Few studies have investigated the relationship between sarcopenia and genotype. A cross-sectional study was conducted with 307 community-dwelling ≥60-year-old women in South Cheshire, UK. Handgrip strength was assessed with a handgrip dynamometer and skeletal muscle mass was estimated using bioelectrical impedance. DNA was extracted from saliva (∼38%) or blood (∼62%) and 24 single-nucleotide polymorphisms (SNPs) were genotyped. Three established sarcopenia definitions - %Skeletal Muscle Mass (%SMM), Skeletal Muscle Mass Index (SMI) and European Working Group on Sarcopenia in Older People (EWGSOP) - were used to assess sarco","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2026-04-30T22:32:12.71Z","creation":"2020-05-22T11:11:54Z"},"accession":"S-EPMC7031370","cross_references":{"pubmed":["32076017"],"doi":["10.1038/s41598-020-59722-9"]}}