biostudies-literatureUnknown10(1)Khanal PErasmus Mundus, MOVE-AGE Joint Doctorate ScholarshipThe prevalence of sarcopenia depends on the definition used. There are, however, consistent sarcopenic characteristics, including a low muscle mass and muscle strength. Few studies have investigated the relationship between sarcopenia and genotype. A cross-sectional study was conducted with 307 community-dwelling ≥60-year-old women in South Cheshire, UK. Handgrip strength was assessed with a handgrip dynamometer and skeletal muscle mass was estimated using bioelectrical impedance. DNA was extracted from saliva (∼38%) or blood (∼62%) and 24 single-nucleotide polymorphisms (SNPs) were genotyped. Three established sarcopenia definitions - %Skeletal Muscle Mass (%SMM), Skeletal Muscle Mass Index (SMI) and European Working Group on Sarcopenia in Older People (EWGSOP) - were used to assess sarcoScientific reports2913https://www.ebi.ac.uk/biostudies/studies/S-EPMC7031370biostudies-literaturePrevalence and association of single nucleotide polymorphisms with sarcopenia in older women depends on definition.PMC7031370Stebbings GKhanal PDegens HHe LOnambele-Pearson GLWilliams AMorse CIThomis MfalsePrevalence and association of single nucleotide polymorphisms with sarcopenia in older women depends on definition.The prevalence of sarcopenia depends on the definition used. There are, however, consistent sarcopenic characteristics, including a low muscle mass and muscle strength. Few studies have investigated the relationship between sarcopenia and genotype. A cross-sectional study was conducted with 307 community-dwelling ≥60-year-old women in South Cheshire, UK. Handgrip strength was assessed with a handgrip dynamometer and skeletal muscle mass was estimated using bioelectrical impedance. DNA was extracted from saliva (∼38%) or blood (∼62%) and 24 single-nucleotide polymorphisms (SNPs) were genotyped. Three established sarcopenia definitions - %Skeletal Muscle Mass (%SMM), Skeletal Muscle Mass Index (SMI) and European Working Group on Sarcopenia in Older People (EWGSOP) - were used to assess sarco2020-01-01T00:00:00Z2020 Feb2026-04-30T22:32:12.71Z2020-05-22T11:11:54ZS-EPMC70313703207601710.1038/s41598-020-59722-9