{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["Pham CV"],"funding":["Ministry of Education, Science and Technology","National Research Foundation of Korea"],"pubmed_abstract":["Until now, there are no publications about the preformulation studies on (S)-zaltoprofen ((S)-ZPF). Hence, we first investigated the solubility of (S)-ZPF, screened solubilizers and performed the pharmacokinetic study of (S)-ZPF in the presence of the solubilizers. The measurement of the solubility of (S)-ZPF in 26 different solvents was carried out, including d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), 2-hydroxypropyl-β-cyclodextrin (HPCD), and mixtures of individual solvent. The plasma concentration of (S)-ZPF and the amount of (S)-ZPF retained in stomach were determined after oral (35.0 mg/kg) and intravenous (5.0 mg/kg) administration. The solubility of (S)-ZPF showed an increase of 484-fold in TPGS compared to its aqueous solubility. There was a significant increase "],"journal":["Asian journal of pharmaceutical sciences"],"pagination":["435-444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7032178"],"repository":["biostudies-literature"],"pubmed_title":["A thorough analysis of the effect of surfactant/s on the solubility and pharmacokinetics of (S)-zaltoprofen."],"pmcid":["PMC7032178"],"pubmed_authors":["Jung SH","Park JH","Baek JS","Cho CW","Pham CV","Kang JS"],"additional_accession":[]},"is_claimable":false,"name":"A thorough analysis of the effect of surfactant/s on the solubility and pharmacokinetics of (S)-zaltoprofen.","description":"Until now, there are no publications about the preformulation studies on (S)-zaltoprofen ((S)-ZPF). Hence, we first investigated the solubility of (S)-ZPF, screened solubilizers and performed the pharmacokinetic study of (S)-ZPF in the presence of the solubilizers. The measurement of the solubility of (S)-ZPF in 26 different solvents was carried out, including d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), 2-hydroxypropyl-β-cyclodextrin (HPCD), and mixtures of individual solvent. The plasma concentration of (S)-ZPF and the amount of (S)-ZPF retained in stomach were determined after oral (35.0 mg/kg) and intravenous (5.0 mg/kg) administration. The solubility of (S)-ZPF showed an increase of 484-fold in TPGS compared to its aqueous solubility. There was a significant increase ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-05-31T22:38:06.983Z","creation":"2025-05-31T22:38:06.983Z"},"accession":"S-EPMC7032178","cross_references":{"pubmed":["32104472"],"doi":["10.1016/j.ajps.2018.10.002"]}}