biostudies-literatureUnknown14(4)Pham CVMinistry of Education, Science and TechnologyNational Research Foundation of KoreaUntil now, there are no publications about the preformulation studies on (S)-zaltoprofen ((S)-ZPF). Hence, we first investigated the solubility of (S)-ZPF, screened solubilizers and performed the pharmacokinetic study of (S)-ZPF in the presence of the solubilizers. The measurement of the solubility of (S)-ZPF in 26 different solvents was carried out, including d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), 2-hydroxypropyl-β-cyclodextrin (HPCD), and mixtures of individual solvent. The plasma concentration of (S)-ZPF and the amount of (S)-ZPF retained in stomach were determined after oral (35.0 mg/kg) and intravenous (5.0 mg/kg) administration. The solubility of (S)-ZPF showed an increase of 484-fold in TPGS compared to its aqueous solubility. There was a significant increase Asian journal of pharmaceutical sciences435-444https://www.ebi.ac.uk/biostudies/studies/S-EPMC7032178biostudies-literatureA thorough analysis of the effect of surfactant/s on the solubility and pharmacokinetics of (S)-zaltoprofen.PMC7032178Jung SHPark JHBaek JSCho CWPham CVKang JSfalseA thorough analysis of the effect of surfactant/s on the solubility and pharmacokinetics of (S)-zaltoprofen.Until now, there are no publications about the preformulation studies on (S)-zaltoprofen ((S)-ZPF). Hence, we first investigated the solubility of (S)-ZPF, screened solubilizers and performed the pharmacokinetic study of (S)-ZPF in the presence of the solubilizers. The measurement of the solubility of (S)-ZPF in 26 different solvents was carried out, including d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), 2-hydroxypropyl-β-cyclodextrin (HPCD), and mixtures of individual solvent. The plasma concentration of (S)-ZPF and the amount of (S)-ZPF retained in stomach were determined after oral (35.0 mg/kg) and intravenous (5.0 mg/kg) administration. The solubility of (S)-ZPF showed an increase of 484-fold in TPGS compared to its aqueous solubility. There was a significant increase 2019-01-01T00:00:00Z2019 Jul2025-05-31T22:38:06.983Z2025-05-31T22:38:06.983ZS-EPMC70321783210447210.1016/j.ajps.2018.10.002