{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mir MA"],"funding":["King Saud University"],"pagination":["975-984"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7042633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(3)"],"pubmed_abstract":["Saffron plant (<i>Crocus sativus</i> L.) is being used as a source of saffron spice and medicine to cure or prevent different types of diseases including cancers. We report the isolation, characterization of bioactive small molecule ([crocetin (β-d-glucosyl) ester] from the leaf biowastes of saffron plant of Kashmir, India. MTTC assay and Bio-autography aided approach were used to assess anti-oxidant activity and anti-cancer properties of crocin (s) against DPPH free radical and breast cancer cell line respectively. Crocetin beta-d-glucosyl ester restrained proliferation of human breast adeno-carcinoma cell model (MCF-7) without significantly affecting normal cell line (L-6). Further studies involving molecular mechanics generalized born surface area and molecular docking showed that croce"],"journal":["Saudi journal of biological sciences"],"pubmed_title":["Isolation, purification and characterization of naturally derived Crocetin beta-d-glucosyl ester from <i>Crocus sativus</i> L. against breast cancer and its binding chemistry with ER-alpha/HDAC2."],"pmcid":["PMC7042633"],"funding_grant_id":["RSP-2019/116"],"pubmed_authors":["Mani P","Masoodi KZ","Rehman MU","Ahmad P","Amin H","Jan S","Ganai SA","Mansoor S","Mir MA"],"additional_accession":[]},"is_claimable":false,"name":"Isolation, purification and characterization of naturally derived Crocetin beta-d-glucosyl ester from <i>Crocus sativus</i> L. against breast cancer and its binding chemistry with ER-alpha/HDAC2.","description":"Saffron plant (<i>Crocus sativus</i> L.) is being used as a source of saffron spice and medicine to cure or prevent different types of diseases including cancers. We report the isolation, characterization of bioactive small molecule ([crocetin (β-d-glucosyl) ester] from the leaf biowastes of saffron plant of Kashmir, India. MTTC assay and Bio-autography aided approach were used to assess anti-oxidant activity and anti-cancer properties of crocin (s) against DPPH free radical and breast cancer cell line respectively. Crocetin beta-d-glucosyl ester restrained proliferation of human breast adeno-carcinoma cell model (MCF-7) without significantly affecting normal cell line (L-6). Further studies involving molecular mechanics generalized born surface area and molecular docking showed that croce","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2025-04-20T02:04:02.546Z","creation":"2020-05-22T12:03:08Z"},"accession":"S-EPMC7042633","cross_references":{"pubmed":["32127777"],"doi":["10.1016/j.sjbs.2020.01.018"]}}