{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["53"],"submitter":["Fujita M"],"funding":["Japan Agency for Medical Research and Development"],"pubmed_abstract":["<h4>Background</h4>The tumor microenvironment can be classified into immunologically active \"inflamed\" tumors and inactive \"non-inflamed\" tumors based on the infiltration of cytotoxic immune cells. Previous studies on liver cancer have reported a superior prognosis for inflamed tumors compared to non-inflamed tumors. However, liver cancer is highly heterogeneous immunologically and genetically, and a finer classification of the liver cancer microenvironment may improve our understanding of its immunological diversity and response to immune therapy.<h4>Methods</h4>We characterized the immune gene signatures of 234 primary liver cancers, mainly virus-related, from a Japanese population using RNA-Seq of tumors and matched non-tumorous hepatitis livers. We then compared them with the somatic a"],"journal":["EBioMedicine"],"pagination":["102659"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7048625"],"repository":["biostudies-literature"],"pubmed_title":["Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations."],"pmcid":["PMC7048625"],"pubmed_authors":["Imoto S","Fujita M","Tanaka H","Hayami S","Shimada S","Yamaue H","Hasegawa T","Chayama K","Arihiro K","Hayashi S","Nakano K","Aikata H","Nakagawa H","Ueno M","Yamaguchi R","Tanaka S","Fujimoto A","Miyano S","Maejima K","Ono A","Kakimi K"],"additional_accession":[]},"is_claimable":false,"name":"Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations.","description":"<h4>Background</h4>The tumor microenvironment can be classified into immunologically active \"inflamed\" tumors and inactive \"non-inflamed\" tumors based on the infiltration of cytotoxic immune cells. Previous studies on liver cancer have reported a superior prognosis for inflamed tumors compared to non-inflamed tumors. However, liver cancer is highly heterogeneous immunologically and genetically, and a finer classification of the liver cancer microenvironment may improve our understanding of its immunological diversity and response to immune therapy.<h4>Methods</h4>We characterized the immune gene signatures of 234 primary liver cancers, mainly virus-related, from a Japanese population using RNA-Seq of tumors and matched non-tumorous hepatitis livers. We then compared them with the somatic a","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2026-05-03T11:24:41.877Z","creation":"2020-05-22T12:05:22Z"},"accession":"S-EPMC7048625","cross_references":{"pubmed":["32113157"],"doi":["10.1016/j.ebiom.2020.102659"]}}