biostudies-literatureUnknown53Fujita MJapan Agency for Medical Research and Development<h4>Background</h4>The tumor microenvironment can be classified into immunologically active "inflamed" tumors and inactive "non-inflamed" tumors based on the infiltration of cytotoxic immune cells. Previous studies on liver cancer have reported a superior prognosis for inflamed tumors compared to non-inflamed tumors. However, liver cancer is highly heterogeneous immunologically and genetically, and a finer classification of the liver cancer microenvironment may improve our understanding of its immunological diversity and response to immune therapy.<h4>Methods</h4>We characterized the immune gene signatures of 234 primary liver cancers, mainly virus-related, from a Japanese population using RNA-Seq of tumors and matched non-tumorous hepatitis livers. We then compared them with the somatic aEBioMedicine102659https://www.ebi.ac.uk/biostudies/studies/S-EPMC7048625biostudies-literatureClassification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations.PMC7048625Imoto SFujita MTanaka HHayami SShimada SYamaue HHasegawa TChayama KArihiro KHayashi SNakano KAikata HNakagawa HUeno MYamaguchi RTanaka SFujimoto AMiyano SMaejima KOno AKakimi KfalseClassification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations.<h4>Background</h4>The tumor microenvironment can be classified into immunologically active "inflamed" tumors and inactive "non-inflamed" tumors based on the infiltration of cytotoxic immune cells. Previous studies on liver cancer have reported a superior prognosis for inflamed tumors compared to non-inflamed tumors. However, liver cancer is highly heterogeneous immunologically and genetically, and a finer classification of the liver cancer microenvironment may improve our understanding of its immunological diversity and response to immune therapy.<h4>Methods</h4>We characterized the immune gene signatures of 234 primary liver cancers, mainly virus-related, from a Japanese population using RNA-Seq of tumors and matched non-tumorous hepatitis livers. We then compared them with the somatic a2020-01-01T00:00:00Z2020 Mar2026-05-03T11:24:41.877Z2020-05-22T12:05:22ZS-EPMC70486253211315710.1016/j.ebiom.2020.102659