biostudies-literatureZhang DYNCATS NIH HHSNINDS NIH HHSNCI NIH HHSNIH HHS477-486https://www.ebi.ac.uk/biostudies/studies/S-EPMC7050644biostudies-literatureUnknown26(2)<h4>Purpose</h4>Paclitaxel shows little benefit in the treatment of glioma due to poor penetration across the blood-brain barrier (BBB). Low-intensity pulsed ultrasound (LIPU) with microbubble injection transiently disrupts the BBB allowing for improved drug delivery to the brain. We investigated the distribution, toxicity, and efficacy of LIPU delivery of two different formulations of paclitaxel, albumin-bound paclitaxel (ABX) and paclitaxel dissolved in cremophor (CrEL-PTX), in preclinical glioma models.<h4>Experimental design</h4>The efficacy and biodistribution of ABX and CrEL-PTX were compared with and without LIPU delivery. Antiglioma activity was evaluated in nude mice bearing intracranial patient-derived glioma xenografts (PDX). Paclitaxel biodistribution was determined in sonicateClinical cancer research : an official journal of the American Association for Cancer ResearchUltrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations.PMC7050644P50 CA221747UL1 TR001422R01 NS102669P30 CA060553DP5 OD021356Canney MDmello CChen LMagnusson LPJames CDSonabend AMKane JRCarpentier AMuzzio MBaran AHorbinski CStupp RZhang DYArrieta VAGonzalez-Buendia EDesseaux CfalseUltrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations.<h4>Purpose</h4>Paclitaxel shows little benefit in the treatment of glioma due to poor penetration across the blood-brain barrier (BBB). Low-intensity pulsed ultrasound (LIPU) with microbubble injection transiently disrupts the BBB allowing for improved drug delivery to the brain. We investigated the distribution, toxicity, and efficacy of LIPU delivery of two different formulations of paclitaxel, albumin-bound paclitaxel (ABX) and paclitaxel dissolved in cremophor (CrEL-PTX), in preclinical glioma models.<h4>Experimental design</h4>The efficacy and biodistribution of ABX and CrEL-PTX were compared with and without LIPU delivery. Antiglioma activity was evaluated in nude mice bearing intracranial patient-derived glioma xenografts (PDX). Paclitaxel biodistribution was determined in sonicate2020-01-01T00:00:00Z2020 Jan2025-04-06T15:17:15.294Z2020-10-29T12:31:30ZS-EPMC70506443183156510.1158/1078-0432.ccr-19-218210.1158/1078-0432.CCR-19-2182