{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(6)"],"submitter":["Fabbri L"],"pubmed_abstract":["<b>Rationale</b>: Renal cell carcinoma (RCC) accounts for about 2% of all adult cancers, and clear cell RCC (ccRCC) is the most common RCC histologic subtype. A hallmark of ccRCC is the loss of the primary cilium, a cellular antenna that senses a wide variety of signals. Loss of this key organelle in ccRCC is associated with the loss of the von Hippel-Lindau protein (VHL). However, not all mechanisms of ciliopathy have been clearly elucidated. <b>Methods</b>: By using RCC4 renal cancer cells and patient samples, we examined the regulation of ciliogenesis <i>via</i> the presence or absence of the hypoxic form of the voltage-dependent anion channel (VDAC1-ΔC) and its impact on tumor aggressiveness. Three independent cohorts were analyzed. Cohort A was from PREDIR and included 12 patients wit"],"journal":["Theranostics"],"pagination":["2696-2713"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7052902"],"repository":["biostudies-literature"],"pubmed_title":["Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients."],"pmcid":["PMC7052902"],"pubmed_authors":["Gardie B","Dufies M","Viotti J","Lacas-Gervais S","Bost F","Mazure NM","Contenti J","Nottet N","Borchiellini D","Chamorey E","Ferrero JM","Sadaghianloo N","Pages G","Fabbri L","Mograbi B","Ambrosetti D","Parola J","Clavel S","Rouleau M","Richard S","Pouyssegur J","Craigen WJ","Gad-Lapiteau S","Meyenberg Cunha de Padua M","Mari B","Leclercq NR"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients.","description":"<b>Rationale</b>: Renal cell carcinoma (RCC) accounts for about 2% of all adult cancers, and clear cell RCC (ccRCC) is the most common RCC histologic subtype. A hallmark of ccRCC is the loss of the primary cilium, a cellular antenna that senses a wide variety of signals. Loss of this key organelle in ccRCC is associated with the loss of the von Hippel-Lindau protein (VHL). However, not all mechanisms of ciliopathy have been clearly elucidated. <b>Methods</b>: By using RCC4 renal cancer cells and patient samples, we examined the regulation of ciliogenesis <i>via</i> the presence or absence of the hypoxic form of the voltage-dependent anion channel (VDAC1-ΔC) and its impact on tumor aggressiveness. Three independent cohorts were analyzed. Cohort A was from PREDIR and included 12 patients wit","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-30T19:50:25.052Z","creation":"2020-05-22T13:42:57Z"},"accession":"S-EPMC7052902","cross_references":{"pubmed":["32194829"],"doi":["10.7150/thno.41001"]}}