biostudies-literatureUnknown10(6)Fabbri L<b>Rationale</b>: Renal cell carcinoma (RCC) accounts for about 2% of all adult cancers, and clear cell RCC (ccRCC) is the most common RCC histologic subtype. A hallmark of ccRCC is the loss of the primary cilium, a cellular antenna that senses a wide variety of signals. Loss of this key organelle in ccRCC is associated with the loss of the von Hippel-Lindau protein (VHL). However, not all mechanisms of ciliopathy have been clearly elucidated. <b>Methods</b>: By using RCC4 renal cancer cells and patient samples, we examined the regulation of ciliogenesis <i>via</i> the presence or absence of the hypoxic form of the voltage-dependent anion channel (VDAC1-ΔC) and its impact on tumor aggressiveness. Three independent cohorts were analyzed. Cohort A was from PREDIR and included 12 patients witTheranostics2696-2713https://www.ebi.ac.uk/biostudies/studies/S-EPMC7052902biostudies-literatureIdentification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients.PMC7052902Gardie BDufies MViotti JLacas-Gervais SBost FMazure NMContenti JNottet NBorchiellini DChamorey EFerrero JMSadaghianloo NPages GFabbri LMograbi BAmbrosetti DParola JClavel SRouleau MRichard SPouyssegur JCraigen WJGad-Lapiteau SMeyenberg Cunha de Padua MMari BLeclercq NRfalseIdentification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients.<b>Rationale</b>: Renal cell carcinoma (RCC) accounts for about 2% of all adult cancers, and clear cell RCC (ccRCC) is the most common RCC histologic subtype. A hallmark of ccRCC is the loss of the primary cilium, a cellular antenna that senses a wide variety of signals. Loss of this key organelle in ccRCC is associated with the loss of the von Hippel-Lindau protein (VHL). However, not all mechanisms of ciliopathy have been clearly elucidated. <b>Methods</b>: By using RCC4 renal cancer cells and patient samples, we examined the regulation of ciliogenesis <i>via</i> the presence or absence of the hypoxic form of the voltage-dependent anion channel (VDAC1-ΔC) and its impact on tumor aggressiveness. Three independent cohorts were analyzed. Cohort A was from PREDIR and included 12 patients wit2020-01-01T00:00:00Z20202026-04-30T19:50:25.052Z2020-05-22T13:42:57ZS-EPMC70529023219482910.7150/thno.41001