biostudies-literatureRodin DNCI NIH HHS915-923https://www.ebi.ac.uk/biostudies/studies/S-EPMC7055962biostudies-literatureUnknown20(7)<h4>Background</h4>Radiotherapy is standard of care for cervical cancer, but major global gaps in access exist, particularly in low-income and middle-income countries. We modelled the health and economic benefits of a 20-year radiotherapy scale-up to estimate the long-term demand for treatment in the context of human papillomavirus (HPV) vaccination.<h4>Methods</h4>We applied the Global Task Force on Radiotherapy for Cancer Control investment framework to model the health and economic benefits of scaling up external-beam radiotherapy and brachytherapy for cervical cancer in upper-middle-income, lower-middle-income, and low-income countries between 2015 and 2035. We estimated the unique costs of external-beam radiotherapy and brachytherapy and included a specific valuation of women's caregiThe Lancet. OncologyScale-up of radiotherapy for cervical cancer in the era of human papillomavirus vaccination in low-income and middle-income countries: a model-based analysis of need and economic impact.PMC7055962K08 CA230170U54 CA190158Grover SZubizarreta EBarton MHanna TPLievens YJaffray DAAtun RRodin DGospodarowicz MBurger EAKnaul FMMilosevic MfalseScale-up of radiotherapy for cervical cancer in the era of human papillomavirus vaccination in low-income and middle-income countries: a model-based analysis of need and economic impact.<h4>Background</h4>Radiotherapy is standard of care for cervical cancer, but major global gaps in access exist, particularly in low-income and middle-income countries. We modelled the health and economic benefits of a 20-year radiotherapy scale-up to estimate the long-term demand for treatment in the context of human papillomavirus (HPV) vaccination.<h4>Methods</h4>We applied the Global Task Force on Radiotherapy for Cancer Control investment framework to model the health and economic benefits of scaling up external-beam radiotherapy and brachytherapy for cervical cancer in upper-middle-income, lower-middle-income, and low-income countries between 2015 and 2035. We estimated the unique costs of external-beam radiotherapy and brachytherapy and included a specific valuation of women's caregi2019-01-01T00:00:00Z2019 Jul2025-04-22T00:21:37.329Z2020-10-29T15:41:40ZS-EPMC70559623115190610.1016/S1470-2045(19)30308-010.1016/s1470-2045(19)30308-0