{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(4)"],"submitter":["Lassche G"],"funding":["Vithèr Hyperthermia B.V."],"pubmed_abstract":["<h4>Background</h4>Extracorporeally induced whole-body hyperthermia (eWBH) might be a beneficial treatment in cancer patients. Objectives of this pig study were to assess thermal distribution, (patho-)physiological effects, and safety of eWBH with a new WBH device.<h4>Methods</h4>Fourteen healthy adult pigs were anesthetized, mechanically ventilated, and cannulated; 12 were included in the analysis. Blood was heated in 11 pigs (one pig served as control) using a WBH device (Vithèr Hyperthermia B.V.) containing two separate fluidic circuits and a heat exchanger. Temperature was monitored on nine different sites, including the brain. Core temperature (average of 4 deep probes) was elevated to 42°C for 2 hr.<h4>Results</h4>Elevation of core body temperature to 42°C took on average (± standard"],"journal":["Physiological reports"],"pagination":["e14366"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7058172"],"repository":["biostudies-literature"],"pubmed_title":["Thermal distribution, physiological effects and toxicities of extracorporeally induced whole-body hyperthermia in a pig model."],"pmcid":["PMC7058172"],"pubmed_authors":["van der Hoeven JG","Lassche G","Jonker MA","Scheffer GJ","van Herpen CML","Mignot MH","Frenzel T"],"additional_accession":[]},"is_claimable":false,"name":"Thermal distribution, physiological effects and toxicities of extracorporeally induced whole-body hyperthermia in a pig model.","description":"<h4>Background</h4>Extracorporeally induced whole-body hyperthermia (eWBH) might be a beneficial treatment in cancer patients. Objectives of this pig study were to assess thermal distribution, (patho-)physiological effects, and safety of eWBH with a new WBH device.<h4>Methods</h4>Fourteen healthy adult pigs were anesthetized, mechanically ventilated, and cannulated; 12 were included in the analysis. Blood was heated in 11 pigs (one pig served as control) using a WBH device (Vithèr Hyperthermia B.V.) containing two separate fluidic circuits and a heat exchanger. Temperature was monitored on nine different sites, including the brain. Core temperature (average of 4 deep probes) was elevated to 42°C for 2 hr.<h4>Results</h4>Elevation of core body temperature to 42°C took on average (± standard","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-04-26T01:49:20.762Z","creation":"2020-05-22T13:21:32Z"},"accession":"S-EPMC7058172","cross_references":{"pubmed":["32097540"],"doi":["10.14814/phy2.14366"]}}