biostudies-literatureUnknown8(4)Lassche GVithèr Hyperthermia B.V.<h4>Background</h4>Extracorporeally induced whole-body hyperthermia (eWBH) might be a beneficial treatment in cancer patients. Objectives of this pig study were to assess thermal distribution, (patho-)physiological effects, and safety of eWBH with a new WBH device.<h4>Methods</h4>Fourteen healthy adult pigs were anesthetized, mechanically ventilated, and cannulated; 12 were included in the analysis. Blood was heated in 11 pigs (one pig served as control) using a WBH device (Vithèr Hyperthermia B.V.) containing two separate fluidic circuits and a heat exchanger. Temperature was monitored on nine different sites, including the brain. Core temperature (average of 4 deep probes) was elevated to 42°C for 2 hr.<h4>Results</h4>Elevation of core body temperature to 42°C took on average (± standardPhysiological reportse14366https://www.ebi.ac.uk/biostudies/studies/S-EPMC7058172biostudies-literatureThermal distribution, physiological effects and toxicities of extracorporeally induced whole-body hyperthermia in a pig model.PMC7058172van der Hoeven JGLassche GJonker MAScheffer GJvan Herpen CMLMignot MHFrenzel TfalseThermal distribution, physiological effects and toxicities of extracorporeally induced whole-body hyperthermia in a pig model.<h4>Background</h4>Extracorporeally induced whole-body hyperthermia (eWBH) might be a beneficial treatment in cancer patients. Objectives of this pig study were to assess thermal distribution, (patho-)physiological effects, and safety of eWBH with a new WBH device.<h4>Methods</h4>Fourteen healthy adult pigs were anesthetized, mechanically ventilated, and cannulated; 12 were included in the analysis. Blood was heated in 11 pigs (one pig served as control) using a WBH device (Vithèr Hyperthermia B.V.) containing two separate fluidic circuits and a heat exchanger. Temperature was monitored on nine different sites, including the brain. Core temperature (average of 4 deep probes) was elevated to 42°C for 2 hr.<h4>Results</h4>Elevation of core body temperature to 42°C took on average (± standard2020-01-01T00:00:00Z2020 Feb2025-04-26T01:49:20.762Z2020-05-22T13:21:32ZS-EPMC70581723209754010.14814/phy2.14366