{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(3)"],"submitter":["Garciaz S"],"pubmed_abstract":["We studied a cohort of 367 healthy related donors who volunteered to donate their hematopoietic stem cells for allogeneic transplantation. All donors were homogeneously cared for at a single institution, and received rhG-CSF as a mobilization treatment prior to undergoing apheresis. Peripheral blood CD34+ cell counts were used as the main surrogate marker for rhG-CSF induced mobilization. We searched whether inter-individual variations in known genetic polymorphisms located in genes whose products are functionally important for mobilization, could affect the extent of CD34+ mobilization, either individually or in combination. We found little or no influence of individual SNPs or haplotypes for the SDF1, CXCR4, VCAM and VLA4 genes, whether using CD34+ cell counts as a continuous or a catego"],"journal":["PloS one"],"pagination":["e0228878"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7058310"],"repository":["biostudies-literature"],"pubmed_title":["Analysis of a large single institution cohort of related donors fails to detect a relation between SDF1/CXCR4 or VCAM/VLA4 genetic polymorphisms and the level of hematopoietic progenitor cell mobilization in response to G-CSF."],"pmcid":["PMC7058310"],"pubmed_authors":["Picard C","Fournel C","di Cristofaro J","Boher JM","Granata A","Lemarie C","Chiaroni J","Sfumato P","Calmels B","Garciaz S","Imbert AM","Chabannon C","Blaise D"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of a large single institution cohort of related donors fails to detect a relation between SDF1/CXCR4 or VCAM/VLA4 genetic polymorphisms and the level of hematopoietic progenitor cell mobilization in response to G-CSF.","description":"We studied a cohort of 367 healthy related donors who volunteered to donate their hematopoietic stem cells for allogeneic transplantation. All donors were homogeneously cared for at a single institution, and received rhG-CSF as a mobilization treatment prior to undergoing apheresis. Peripheral blood CD34+ cell counts were used as the main surrogate marker for rhG-CSF induced mobilization. We searched whether inter-individual variations in known genetic polymorphisms located in genes whose products are functionally important for mobilization, could affect the extent of CD34+ mobilization, either individually or in combination. We found little or no influence of individual SNPs or haplotypes for the SDF1, CXCR4, VCAM and VLA4 genes, whether using CD34+ cell counts as a continuous or a catego","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-29T13:15:58.888Z","creation":"2020-05-22T13:21:57Z"},"accession":"S-EPMC7058310","cross_references":{"pubmed":["32134938"],"doi":["10.1371/journal.pone.0228878"]}}