{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["She D"],"funding":["National Natural Science Foundation of China"],"pagination":["152"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7060591"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by extraskeletal heterotopic ossification. It is well recognized that FOP can lead to a devastating condition of disability. However, the mortality rate of FOP patients in China and risk factors for mortality are still largely unclear.<h4>Methods</h4>We conducted a retrospective research on a cohort of 65 cases of FOP patients in China from 2008 to 2018. We reviewed medical records of these FOP patients to retrieve information such as date of birth/death, gender, clinical features, genotypes and biochemical parameters and analyze the correlation of these parameters with the mortality.<h4>Results</h4>92.3% (60/65 cases) patients were classic FOP patients, 3.1% (2/65 cases) were FOP"],"journal":["BMC musculoskeletal disorders"],"pubmed_title":["Serum osteocalcin level is associated with the mortality in Chinese patients with Fibrodysplasia ossificans progressiva aged ≤18 years at diagnosis."],"pmcid":["PMC7060591"],"funding_grant_id":["81670805","81400834","81974105"],"pubmed_authors":["Zhang K","She D","Zong G","Fang P","Li R","Xue Y"],"additional_accession":[]},"is_claimable":false,"name":"Serum osteocalcin level is associated with the mortality in Chinese patients with Fibrodysplasia ossificans progressiva aged ≤18 years at diagnosis.","description":"<h4>Background</h4>Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by extraskeletal heterotopic ossification. It is well recognized that FOP can lead to a devastating condition of disability. However, the mortality rate of FOP patients in China and risk factors for mortality are still largely unclear.<h4>Methods</h4>We conducted a retrospective research on a cohort of 65 cases of FOP patients in China from 2008 to 2018. We reviewed medical records of these FOP patients to retrieve information such as date of birth/death, gender, clinical features, genotypes and biochemical parameters and analyze the correlation of these parameters with the mortality.<h4>Results</h4>92.3% (60/65 cases) patients were classic FOP patients, 3.1% (2/65 cases) were FOP","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2026-04-16T21:07:50.062Z","creation":"2020-05-22T13:01:42Z"},"accession":"S-EPMC7060591","cross_references":{"pubmed":["32143615"],"doi":["10.1186/s12891-020-3170-3"]}}