biostudies-literatureShe DNational Natural Science Foundation of China152https://www.ebi.ac.uk/biostudies/studies/S-EPMC7060591biostudies-literatureUnknown21(1)<h4>Background</h4>Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by extraskeletal heterotopic ossification. It is well recognized that FOP can lead to a devastating condition of disability. However, the mortality rate of FOP patients in China and risk factors for mortality are still largely unclear.<h4>Methods</h4>We conducted a retrospective research on a cohort of 65 cases of FOP patients in China from 2008 to 2018. We reviewed medical records of these FOP patients to retrieve information such as date of birth/death, gender, clinical features, genotypes and biochemical parameters and analyze the correlation of these parameters with the mortality.<h4>Results</h4>92.3% (60/65 cases) patients were classic FOP patients, 3.1% (2/65 cases) were FOPBMC musculoskeletal disordersSerum osteocalcin level is associated with the mortality in Chinese patients with Fibrodysplasia ossificans progressiva aged ≤18 years at diagnosis.PMC7060591816708058140083481974105Zhang KShe DZong GFang PLi RXue YfalseSerum osteocalcin level is associated with the mortality in Chinese patients with Fibrodysplasia ossificans progressiva aged ≤18 years at diagnosis.<h4>Background</h4>Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by extraskeletal heterotopic ossification. It is well recognized that FOP can lead to a devastating condition of disability. However, the mortality rate of FOP patients in China and risk factors for mortality are still largely unclear.<h4>Methods</h4>We conducted a retrospective research on a cohort of 65 cases of FOP patients in China from 2008 to 2018. We reviewed medical records of these FOP patients to retrieve information such as date of birth/death, gender, clinical features, genotypes and biochemical parameters and analyze the correlation of these parameters with the mortality.<h4>Results</h4>92.3% (60/65 cases) patients were classic FOP patients, 3.1% (2/65 cases) were FOP2020-01-01T00:00:00Z2020 Mar2026-04-16T21:07:50.062Z2020-05-22T13:01:42ZS-EPMC70605913214361510.1186/s12891-020-3170-3