{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martin JC"],"funding":["Sanford J. Grossman Charitable Trust","Fondation Bettencourt-Schueller","Philippe Foundation","NIDDK NIH HHS","NIAID NIH HHS","Crohn's & Colitis Foundation","Crohn's and Colitis Foundation","NCI NIH HHS","NIH","NIH HHS","Boehringer Ingelheim Pharmaceuticals"],"pagination":["1493-1508.e20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7060942"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["178(6)"],"pubmed_abstract":["Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of patients. Here, we applied single-cell technologies to iCD lesions to address whether cellular heterogeneity contributes to treatment resistance. We found that a subset of patients expressed a unique cellular module in inflamed tissues that consisted of IgG plasma cells, inflammatory mononuclear phagocytes, activated T cells, and stromal cells, which we named the GIMATS module. Analysis of ligand-receptor interaction pairs identified a distinct network connectivity that likely drives the GIMATS module. Strikingly, the GIMATS module was also present in a subset of patients in four independent iCD cohorts (n = 441), and its presence at diagnosis correlated with failure to achieve durable corticos"],"journal":["Cell"],"pubmed_title":["Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy."],"pmcid":["PMC7060942"],"funding_grant_id":["U24 CA224319","S10 OD023547-01","U24 DK062429","R56AI137244","U19 AI128949","558865","S10 OD018522","292052","R01 DK106593","U01 DK062422","K23 DK111995","U24 AI118644","274356","U01 DK062429","R56 AI137244","R01 CA190400","419130","K23KD111995-01A1","S10 OD023547","T32 CA078207","1878"],"pubmed_authors":["Ungaro R","Chuang LS","Giri M","Martin JC","Merad M","Salmon H","Boschetti G","Denson LA","Kugathasan S","Mbow ML","Fine JS","Hyams JS","Akturk G","Cho JH","Kenigsberg E","Greenstein AJ","Chang C","Grout JA","Walker L","Desai PT","Nayar S","Whitehurst CE","Gnjatic S","Rahman AH","Leader A","Schadt EE","Ko HM","Laface I","Friedman JR","Gettler K","Dubinsky M"],"additional_accession":[]},"is_claimable":false,"name":"Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.","description":"Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of patients. Here, we applied single-cell technologies to iCD lesions to address whether cellular heterogeneity contributes to treatment resistance. We found that a subset of patients expressed a unique cellular module in inflamed tissues that consisted of IgG plasma cells, inflammatory mononuclear phagocytes, activated T cells, and stromal cells, which we named the GIMATS module. Analysis of ligand-receptor interaction pairs identified a distinct network connectivity that likely drives the GIMATS module. Strikingly, the GIMATS module was also present in a subset of patients in four independent iCD cohorts (n = 441), and its presence at diagnosis correlated with failure to achieve durable corticos","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-05-04T08:38:15.921Z","creation":"2020-10-29T14:21:52Z"},"accession":"S-EPMC7060942","cross_references":{"pubmed":["31474370"],"doi":["10.1016/j.cell.2019.08.008"]}}