biostudies-literaturePharaoh GNational Institute of Neurological Disorders and StrokeNIA NIH HHSNINDS NIH HHSNational Institute on AgingNIGMS NIH HHS1317-1331https://www.ebi.ac.uk/biostudies/studies/S-EPMC7060968biostudies-literatureUnknown57(3)Age-related decline in circulating levels of insulin-like growth factor (IGF)-1 is associated with reduced cognitive function, neuronal aging, and neurodegeneration. Decreased mitochondrial function along with increased reactive oxygen species (ROS) and accumulation of damaged macromolecules are hallmarks of cellular aging. Based on numerous studies indicating pleiotropic effects of IGF-1 during aging, we compared the central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function using an inducible liver IGF-1 knockout (LID). Circulating levels of IGF-1 (~ 75%) were depleted in adult male Igf1^f/f mice via AAV-mediated knockdown of hepatic IGF-1 at 5 months of age. Cognitive function was evaluated at 18 months using the radial arm water maze and gMolecular neurobiologyDisparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function.PMC7060968P20 GM103447R01AG038747T32AG052363K99AG056662R01NS056218K99 AG056662P30AG050911Ashpole NPremkumar PBhaskaran SKinter MPharaoh GVan Remmen HLogan SYeganeh AFarley JOwen DfalseDisparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function.Age-related decline in circulating levels of insulin-like growth factor (IGF)-1 is associated with reduced cognitive function, neuronal aging, and neurodegeneration. Decreased mitochondrial function along with increased reactive oxygen species (ROS) and accumulation of damaged macromolecules are hallmarks of cellular aging. Based on numerous studies indicating pleiotropic effects of IGF-1 during aging, we compared the central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function using an inducible liver IGF-1 knockout (LID). Circulating levels of IGF-1 (~ 75%) were depleted in adult male Igf1^f/f mice via AAV-mediated knockdown of hepatic IGF-1 at 5 months of age. Cognitive function was evaluated at 18 months using the radial arm water maze and g2020-01-01T00:00:00Z2020 Mar2025-05-18T12:58:23.99Z2025-05-18T12:58:23.99ZS-EPMC70609683173291210.1007/s12035-019-01821-4