{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4"],"submitter":["Leferink AM"],"funding":["the Dutch Province of Limburg","Kyeron B.V."],"pubmed_abstract":["In bottom-up tissue engineering, small modular units of cells and biomaterials are assembled toward ​larger and more complex ones. In conjunction with a new implementation of this approach, a novel method to fabricate microscale objects from biopolymers by thermal imprinting on water-soluble sacrificial layers is presented. By this means, geometrically well-defined objects could be obtained without involving toxic agents in the form of photoinitiators. The micro-objects were used as cell-adhesive substrates and cell spacers in engineered tissues created by cell-guided assembly of the objects. Such constructs can be applied both for in vitro studies and clinical treatments. Clinically relevantly sized aggregates comprised of cells and micro-objects retained their viability up to 2 weeks of "],"journal":["Materials today. Bio"],"pagination":["100025"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7061620"],"repository":["biostudies-literature"],"pubmed_title":["Shape-defined solid micro-objects from poly(d,l-lactic acid) as cell-supportive counterparts in bottom-up tissue engineering."],"pmcid":["PMC7061620"],"pubmed_authors":["Bossink EGBM","Moroni L","van den Berg A","van Vossen H","de Heus LE","Leferink AM","Tibbe MP","Truckenmuller RK"],"additional_accession":[]},"is_claimable":false,"name":"Shape-defined solid micro-objects from poly(d,l-lactic acid) as cell-supportive counterparts in bottom-up tissue engineering.","description":"In bottom-up tissue engineering, small modular units of cells and biomaterials are assembled toward ​larger and more complex ones. In conjunction with a new implementation of this approach, a novel method to fabricate microscale objects from biopolymers by thermal imprinting on water-soluble sacrificial layers is presented. By this means, geometrically well-defined objects could be obtained without involving toxic agents in the form of photoinitiators. The micro-objects were used as cell-adhesive substrates and cell spacers in engineered tissues created by cell-guided assembly of the objects. Such constructs can be applied both for in vitro studies and clinical treatments. Clinically relevantly sized aggregates comprised of cells and micro-objects retained their viability up to 2 weeks of ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-05T16:10:45.295Z","creation":"2020-05-22T13:03:14Z"},"accession":"S-EPMC7061620","cross_references":{"pubmed":["32159154"],"doi":["10.1016/j.mtbio.2019.100025"]}}