biostudies-literatureNiu RWuhan UniversityNational Natural Science Foundation of Chinabaaa007https://www.ebi.ac.uk/biostudies/studies/S-EPMC7068905biostudies-literatureUnknown2020Upstream open reading frames (uORFs) are prevalent in eukaryotic mRNAs. They act as a translational control element for precisely tuning the expression of the downstream major open reading frame (mORF). uORF variation has been clearly associated with several human diseases. In contrast, natural uORF variants in plants have not ever been identified or linked with any phenotypic changes. The paucity of such evidence encouraged us to generate this database-uORFlight (http://uorflight.whu.edu.cn). It facilitates the exploration of uORF variation among different splicing models of Arabidopsis and rice genes. Most importantly, users can evaluate uORF frequency among different accessions at the population scale and find out the causal single nucleotide polymorphism (SNP) or insertion/deletion (INDatabase : the journal of biological databases and curationuORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes.PMC706890531822042Niu RTang ZMou RZhang YZhou GGuo SYuan MZhou YWang ZXu GfalseuORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes.Upstream open reading frames (uORFs) are prevalent in eukaryotic mRNAs. They act as a translational control element for precisely tuning the expression of the downstream major open reading frame (mORF). uORF variation has been clearly associated with several human diseases. In contrast, natural uORF variants in plants have not ever been identified or linked with any phenotypic changes. The paucity of such evidence encouraged us to generate this database-uORFlight (http://uorflight.whu.edu.cn). It facilitates the exploration of uORF variation among different splicing models of Arabidopsis and rice genes. Most importantly, users can evaluate uORF frequency among different accessions at the population scale and find out the causal single nucleotide polymorphism (SNP) or insertion/deletion (IN2020-01-01T00:00:00Z2020 Jan2026-07-15T18:29:01.211Z2026-07-09T03:08:20.906ZS-EPMC70689053216837410.1093/database/baaa007