{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo Y"],"funding":["National Key R&amp;D Program of China","NCATS NIH HHS","National Natural Science Foundation of China","National Institutes of Health","NIH","NIGMS NIH HHS"],"pagination":["1881-1897"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7070165"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["177(8)"],"pubmed_abstract":["<h4>Background and purpose</h4>Lipopolysaccharides (LPS), an outer membrane component of Gram-negative bacteria, triggers myocardial anomalies in sepsis. Recent findings indicated a role for inflammatory cytokine MIF and its receptor, CD74, in septic organ injury, although little is known of the role of MIF-CD74 in septic cardiomyopathy.<h4>Experimental approach</h4>This study evaluated the impact of CD74 ablation on endotoxaemia-induced cardiac anomalies. Echocardiographic, cardiomyocyte contractile and intracellular Ca<sup>2+</sup> properties were examined.<h4>Key results</h4>Our data revealed compromised cardiac function (lower fractional shortening, enlarged LV end systolic diameter, decreased peak shortening, maximal velocity of shortening/relengthening, prolonged duration of relength"],"journal":["British journal of pharmacology"],"pubmed_title":["CD74 knockout protects against LPS-induced myocardial contractile dysfunction through AMPK-Skp2-SUV39H1-mediated demethylation of BCLB."],"pmcid":["PMC7070165"],"funding_grant_id":["81570225","81372055","81522004","T32 GM007205","UL1 TR001863","81571895","81770261","2017YFA0506000"],"pubmed_authors":["Zhang Y","Ren J","Yang M","Bucala R","Dong M","Pei Z","Luo Y","Fan C"],"additional_accession":[]},"is_claimable":false,"name":"CD74 knockout protects against LPS-induced myocardial contractile dysfunction through AMPK-Skp2-SUV39H1-mediated demethylation of BCLB.","description":"<h4>Background and purpose</h4>Lipopolysaccharides (LPS), an outer membrane component of Gram-negative bacteria, triggers myocardial anomalies in sepsis. Recent findings indicated a role for inflammatory cytokine MIF and its receptor, CD74, in septic organ injury, although little is known of the role of MIF-CD74 in septic cardiomyopathy.<h4>Experimental approach</h4>This study evaluated the impact of CD74 ablation on endotoxaemia-induced cardiac anomalies. Echocardiographic, cardiomyocyte contractile and intracellular Ca<sup>2+</sup> properties were examined.<h4>Key results</h4>Our data revealed compromised cardiac function (lower fractional shortening, enlarged LV end systolic diameter, decreased peak shortening, maximal velocity of shortening/relengthening, prolonged duration of relength","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2026-05-03T20:02:55.118Z","creation":"2022-02-10T17:11:27.842Z"},"accession":"S-EPMC7070165","cross_references":{"pubmed":["31877229"],"doi":["10.1111/bph.14959"]}}