biostudies-literatureLuo YNational Key R&amp;D Program of ChinaNCATS NIH HHSNational Natural Science Foundation of ChinaNational Institutes of HealthNIHNIGMS NIH HHS1881-1897https://www.ebi.ac.uk/biostudies/studies/S-EPMC7070165biostudies-literatureUnknown177(8)<h4>Background and purpose</h4>Lipopolysaccharides (LPS), an outer membrane component of Gram-negative bacteria, triggers myocardial anomalies in sepsis. Recent findings indicated a role for inflammatory cytokine MIF and its receptor, CD74, in septic organ injury, although little is known of the role of MIF-CD74 in septic cardiomyopathy.<h4>Experimental approach</h4>This study evaluated the impact of CD74 ablation on endotoxaemia-induced cardiac anomalies. Echocardiographic, cardiomyocyte contractile and intracellular Ca²⁺ properties were examined.<h4>Key results</h4>Our data revealed compromised cardiac function (lower fractional shortening, enlarged LV end systolic diameter, decreased peak shortening, maximal velocity of shortening/relengthening, prolonged duration of relengthBritish journal of pharmacologyCD74 knockout protects against LPS-induced myocardial contractile dysfunction through AMPK-Skp2-SUV39H1-mediated demethylation of BCLB.PMC7070165815702258137205581522004T32 GM007205UL1 TR00186381571895817702612017YFA0506000Zhang YRen JYang MBucala RDong MPei ZLuo YFan CfalseCD74 knockout protects against LPS-induced myocardial contractile dysfunction through AMPK-Skp2-SUV39H1-mediated demethylation of BCLB.<h4>Background and purpose</h4>Lipopolysaccharides (LPS), an outer membrane component of Gram-negative bacteria, triggers myocardial anomalies in sepsis. Recent findings indicated a role for inflammatory cytokine MIF and its receptor, CD74, in septic organ injury, although little is known of the role of MIF-CD74 in septic cardiomyopathy.<h4>Experimental approach</h4>This study evaluated the impact of CD74 ablation on endotoxaemia-induced cardiac anomalies. Echocardiographic, cardiomyocyte contractile and intracellular Ca²⁺ properties were examined.<h4>Key results</h4>Our data revealed compromised cardiac function (lower fractional shortening, enlarged LV end systolic diameter, decreased peak shortening, maximal velocity of shortening/relengthening, prolonged duration of relength2020-01-01T00:00:00Z2020 Apr2026-05-03T20:02:55.118Z2022-02-10T17:11:27.842ZS-EPMC70701653187722910.1111/bph.14959