biostudies-literatureUnknown25(4)Vega Alanis BAAustrian Science Fund FWFGABAA receptor modulators are structurally almost as diverse as their target protein. A plethora of heterocyclic scaffolds has been described as modulating this extremely important receptor family. Some made it into clinical trials and, even on the market, some were dismissed. This review focuses on the synthetic accessibility and potential for library synthesis of GABAA receptor modulators containing at least one heterocyclic scaffold, which were disclosed within the last 10 years.Molecules (Basel, Switzerland)https://www.ebi.ac.uk/biostudies/studies/S-EPMC7070463biostudies-literatureAllosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility.PMC7070463W1232Bampali KErnst MMihovilovic MDVega Alanis BAIorio MTSilva LLSchnurch MfalseAllosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility.GABAA receptor modulators are structurally almost as diverse as their target protein. A plethora of heterocyclic scaffolds has been described as modulating this extremely important receptor family. Some made it into clinical trials and, even on the market, some were dismissed. This review focuses on the synthetic accessibility and potential for library synthesis of GABAA receptor modulators containing at least one heterocyclic scaffold, which were disclosed within the last 10 years.2020-01-01T00:00:00Z2020 Feb2020-05-22T13:47:35Z2020-05-22T13:47:35ZS-EPMC70704633210230910.3390/molecules25040999