{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Omnus DJ"],"funding":["Medical Research Council","Wenner-Gren Foundations"],"pagination":["28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7071650"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["BACKGROUND:Phosphoinositide lipids provide spatial landmarks during polarized cell growth and migration. Yet how phosphoinositide gradients are oriented in response to extracellular cues and environmental conditions is not well understood. Here, we elucidate an unexpected mode of phosphatidylinositol 4-phosphate (PI4P) regulation in the control of polarized secretion. RESULTS:We show that PI4P is highly enriched at the plasma membrane of growing daughter cells in budding yeast where polarized secretion occurs. However, upon heat stress conditions that redirect secretory traffic, PI4P rapidly increases at the plasma membrane in mother cells resulting in a more uniform PI4P distribution. Precise control of PI4P distribution is mediated through the Osh (oxysterol-binding protein homology) pro"],"journal":["BMC biology"],"pubmed_title":["A heat-sensitive Osh protein controls PI4P polarity."],"pmcid":["PMC7071650"],"funding_grant_id":["NA","MC_UU_00012/6"],"pubmed_authors":["Cadou A","Bader JM","Vaughan AN","Omnus DJ","Thomas FB","Chung GHC","Stefan CJ","Soh N"],"additional_accession":[]},"is_claimable":false,"name":"A heat-sensitive Osh protein controls PI4P polarity.","description":"BACKGROUND:Phosphoinositide lipids provide spatial landmarks during polarized cell growth and migration. Yet how phosphoinositide gradients are oriented in response to extracellular cues and environmental conditions is not well understood. Here, we elucidate an unexpected mode of phosphatidylinositol 4-phosphate (PI4P) regulation in the control of polarized secretion. RESULTS:We show that PI4P is highly enriched at the plasma membrane of growing daughter cells in budding yeast where polarized secretion occurs. However, upon heat stress conditions that redirect secretory traffic, PI4P rapidly increases at the plasma membrane in mother cells resulting in a more uniform PI4P distribution. Precise control of PI4P distribution is mediated through the Osh (oxysterol-binding protein homology) pro","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2025-04-04T03:29:41.11Z","creation":"2020-05-22T13:27:09Z"},"accession":"S-EPMC7071650","cross_references":{"pubmed":["32169085"],"doi":["10.1186/s12915-020-0758-x"]}}