{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Appleton JP"],"funding":["Medical Research Council"],"pagination":["e439-e452"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7080284"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["94(5)"],"pubmed_abstract":["Objective
To assess the association of baseline imaging markers of cerebral small vessel disease (SVD) and brain frailty with clinical outcome after acute stroke in the Efficacy of Nitric Oxide in Stroke (ENOS) trial.Methods
ENOS randomized 4,011 patients with acute stroke (<48 hours of onset) to transdermal glyceryl trinitrate (GTN) or no GTN for 7 days. The primary outcome was functional outcome (modified Rankin Scale [mRS] score) at day 90. Cognition was assessed via telephone at day 90. Stroke syndrome was classified with the Oxfordshire Community Stroke Project classification. Brain imaging was adjudicated masked to clinical information and treatment and assessed SVD (leukoaraiosis, old lacunar infarcts/lacunes, atrophy) and brain frailty (leukoaraiosis, atrophy, old v"],"journal":["Neurology"],"pubmed_title":["Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke."],"pmcid":["PMC7080284"],"funding_grant_id":["G0501797","UKDRI-4002"],"pubmed_authors":["Amarenco A","Gommans J","El Etribi A","Ghani AR","Thomas D","Pocock S","Beridze M","Laska AC","Prasad K","de Silva HA","Appleton JP","Navarro J","Lees KR","Adami A","Wong L","Berge E","Bath PM","D´ıez- Tejedor E","Muir K","Shone A","Whynes D","Woodhouse LJ","Koumellis P","Cala LA","Venables G","Szatmari S","Collins R","Ntaios G","Chang HM","Phillips S","Wardlaw JM","Chen C","Wang YJ","Caso V","Bladin C","Becker JL","Casado AM","Ozturk S","Sprigg N","ENOS Investigators","Dineen RA","Skene A","Czlonkowska A","Christensen HK"],"additional_accession":[]},"is_claimable":false,"name":"Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke.","description":"Objective
To assess the association of baseline imaging markers of cerebral small vessel disease (SVD) and brain frailty with clinical outcome after acute stroke in the Efficacy of Nitric Oxide in Stroke (ENOS) trial.Methods
ENOS randomized 4,011 patients with acute stroke (<48 hours of onset) to transdermal glyceryl trinitrate (GTN) or no GTN for 7 days. The primary outcome was functional outcome (modified Rankin Scale [mRS] score) at day 90. Cognition was assessed via telephone at day 90. Stroke syndrome was classified with the Oxfordshire Community Stroke Project classification. Brain imaging was adjudicated masked to clinical information and treatment and assessed SVD (leukoaraiosis, old lacunar infarcts/lacunes, atrophy) and brain frailty (leukoaraiosis, atrophy, old v","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-04-18T18:40:28.522Z","creation":"2020-05-22T14:25:17Z"},"accession":"S-EPMC7080284","cross_references":{"pubmed":["31882527"],"doi":["10.1212/WNL.0000000000008881"]}}