{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Lawrence MG"],"pubmed_abstract":["<h4>Background</h4>Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts (CAFs) coincide with alterations in DNA methylation levels at loci-specific regulatory regions. Yet, it is not clear how these methylation changes compare across CAFs from different patients. Therefore, we examined the consistency and prognostic significance of genome-wide DNA methylation profiles between CAFs from patients with different grades of primary prostate cancer.<h4>Results</h4>We used Infinium MethylationEPIC BeadChips to evaluate genome-wide DNA methylation profiles from 18 matched CAFs and non-malignant prostate tissue fibroblasts (NPFs) from men with "],"journal":["Clinical epigenetics"],"pagination":["48"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7081708"],"repository":["biostudies-literature"],"pubmed_title":["Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer."],"pmcid":["PMC7081708"],"pubmed_authors":["Pereira BA","Lawrence MG","Frydenberg M","Risbridger GP","Pidsley R","Richards M","Norden S","Clark SJ","Teng L","Papargiris M","Ryan A","Taylor RA","Niranjan B","Stirzaker C"],"additional_accession":[]},"is_claimable":false,"name":"Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer.","description":"<h4>Background</h4>Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts (CAFs) coincide with alterations in DNA methylation levels at loci-specific regulatory regions. Yet, it is not clear how these methylation changes compare across CAFs from different patients. Therefore, we examined the consistency and prognostic significance of genome-wide DNA methylation profiles between CAFs from patients with different grades of primary prostate cancer.<h4>Results</h4>We used Infinium MethylationEPIC BeadChips to evaluate genome-wide DNA methylation profiles from 18 matched CAFs and non-malignant prostate tissue fibroblasts (NPFs) from men with ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2026-04-29T17:36:00.409Z","creation":"2020-05-22T14:03:26Z"},"accession":"S-EPMC7081708","cross_references":{"pubmed":["32188493"],"doi":["10.1186/s13148-020-00836-2"]}}