{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thompson PM"],"funding":["MRF","NIBIB NIH HHS","NICHD NIH HHS","NCATS NIH HHS","NIDA NIH HHS","NIA NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Aging","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","Department of Health | National Health and Medical Research Council","U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering","Medical Research Foundation","Deutsche Forschungsgemeinschaft","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","Deutsche Forschungsgemeinschaft (German Research Foundation)","Medical Research Council","ODCDC CDC HHS","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","NINDS NIH HHS","Department of Health | National Health and Medical Research Council (NHMRC)","NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health"],"pagination":["100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7083923"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmoni"],"journal":["Translational psychiatry"],"pubmed_title":["ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries."],"pmcid":["PMC7083923"],"funding_grant_id":["MRF-058-0004-RG-DESRI","R01 MH117601","APP1103623","MR/R00465X/1","T32 AG058507","U54 EB020403","UL1 TR001863","R01 AG059874","MR/S020306/1","U01 MH108148","S10 OD023696","R21 NS107739","R01 NS107739","R21 MH116473","R56 AG058854","K01 HD091283","MRF_MRF-058-0004-RG-DESRI","R01 MH111671","R01 MH085953","APP1158127","R01 EB015611","MRF_MRF-058-0009-RG-DESR-C0759","R01 MH116147","MR/L016311/1","MRF-058-0009-RG-DESR-C0759","R01 NS115845","R01 DA047119","WA1539/11-1","ER724/4-1"],"pubmed_authors":["Hajek T","Zhang G","Altmann A","Pozzi E","Volzke H","Bearden CE","Baune BT","Knickmeyer RC","Chye Y","Faraone SV","Aghajani M","Jalbrzikowski M","van der Werf YD","Aleman A","Ching CRK","Filippi CA","Grabe HJ","Adhikari BM","Althoff RR","Fouche JP","Shiroishi MS","Ho TC","de Zwarte SMC","Walter H","van den Heuvel OA","van Velzen LS","Van Someren EJW","van der Merwe C","Kochunov P","Favre P","Stein JL","Berner LA","Hahn T","Villalon-Reina JE","Grasby KL","Mukherjee P","Nunes A","Koerte IK","Shatokhina N","Pizzagalli F","Piras F","Kelly S","Pine DS","Liew SL","Bralten J","Franke B","Klapwijk ET","McMahon AB","Marie Bas-Hoogendam J","Fairchild G","Eyler LT","Turner JA","Lueken U","Brouwer RM","Nir TM","Zelman V","Bright J","Samann PG","Glahn DC","Hilbert K","Salminen LE","Cecil CAM","Wittfeld K","Francks C","Renteria ME","Klein M","Buitelaar JK","Hulshoff Pol HE","Laansma MA","Baron DA","Garijo D","Luders E","Mayer AR","Neill JO","Schmaal L","Hernaus D","Stein DJ","Dannlowski U","Agartz I","Teumer A","Gil Y","Olsen A","van Erp TGM","Veer IM","Dennis EL","Postema MC","Mueller SC","Paschou P","Modinos G","Tahmasian M","Tate DF","Groenewold NA","de Kovel CGF","Baskin-Sommers AR","Bertolin S","Zhang-James Y","Hoogman M","Wang L","Winkler AM","Ehrlich S","Leerssen J","Walton E","Andreassen OA","Hibar DP","Soriano-Mas C","Fisher SE","Lin AP","Medland SE","Ivanov I","Sun D","Logue MW","van Wingen GA","Conrod PJ","Macciardi F","Rohrer JD","Chen J","Hatton SN","Caeyenberghs K","Smit DJA","Hosten N","Gutman BA","Holleran L","Donohoe G","Zarei M","Bartnik-Olson BL","Namazova-Baranova L","Garavan HP","Whelan CD","Thompson PM","Schumann G","Opel N","Tozzi L","Spalletta G","Karkashadze GA","van der Wee NJA","Tilot AK","De Brito SA","Desrivieres S","ENIGMA Consortium","Hillary FG","Frangou S","Kwon JS","Gurholt TP","van Haren NEM","Wilde EA","McDonald CR","Houenou J","Boedhoe PSW","Sonderby IE","Jia T","Cohen RA","Dima D","Bulow R","Harding IH","Wright MJ","Kong XZ","Esopenko C","Jahanshad N","Veltman DJ","Homuth G","Han LKM","Sisodiya SM","Cole JH","Bruin WB","Morey RA","Thomopoulos SI","Frodl T","Mackey S","van Rooij D","Yun JY"],"additional_accession":[]},"is_claimable":false,"name":"ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.","description":"This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmoni","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2025-04-19T07:43:32.426Z","creation":"2020-05-22T14:24:23Z"},"accession":"S-EPMC7083923","cross_references":{"pubmed":["32198361"],"doi":["10.1038/s41398-020-0705-1"]}}