{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Walter A"],"funding":["Deutsche Forschungsgemeinschaft","UK Research and Innovation | Medical Research Council","Medical Research Council","Wellcome Trust"],"pagination":["4024-4034"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7086022"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["295(12)"],"pubmed_abstract":["The cell envelope of Gram-positive bacteria generally comprises two types of polyanionic polymers linked to either peptidoglycan (wall teichoic acids; WTA) or to membrane glycolipids (lipoteichoic acids; LTA). In some bacteria, including <i>Bacillus subtilis</i> strain 168, both WTA and LTA are glycerolphosphate polymers yet are synthesized through different pathways and have distinct but incompletely understood morphogenetic functions during cell elongation and division. We show here that the exolytic <i>sn</i>-glycerol-3-phosphodiesterase GlpQ can discriminate between <i>B. subtilis</i> WTA and LTA. GlpQ completely degraded unsubstituted WTA, which lacks substituents at the glycerol residues, by sequentially removing glycerolphosphates from the free end of the polymer up to the peptidogl"],"journal":["The Journal of biological chemistry"],"pubmed_title":["Phosphoglycerol-type wall and lipoteichoic acids are enantiomeric polymers differentiated by the stereospecific glycerophosphodiesterase GlpQ."],"pmcid":["PMC7086022"],"funding_grant_id":["GRK1708","MR/P011071/1","RI 2920/1–1","MR/P028225/1","SFB766","EXC 2124","TRR 261","210671/Z/18/Z","TRR 34","TRR 156"],"pubmed_authors":["Walter A","Peschel A","Rismondo J","Grundling A","Mayer C","Jorge AM","Unsleber S"],"additional_accession":[]},"is_claimable":false,"name":"Phosphoglycerol-type wall and lipoteichoic acids are enantiomeric polymers differentiated by the stereospecific glycerophosphodiesterase GlpQ.","description":"The cell envelope of Gram-positive bacteria generally comprises two types of polyanionic polymers linked to either peptidoglycan (wall teichoic acids; WTA) or to membrane glycolipids (lipoteichoic acids; LTA). In some bacteria, including <i>Bacillus subtilis</i> strain 168, both WTA and LTA are glycerolphosphate polymers yet are synthesized through different pathways and have distinct but incompletely understood morphogenetic functions during cell elongation and division. We show here that the exolytic <i>sn</i>-glycerol-3-phosphodiesterase GlpQ can discriminate between <i>B. subtilis</i> WTA and LTA. GlpQ completely degraded unsubstituted WTA, which lacks substituents at the glycerol residues, by sequentially removing glycerolphosphates from the free end of the polymer up to the peptidogl","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2026-04-30T17:41:25.827Z","creation":"2020-05-22T14:30:31Z"},"accession":"S-EPMC7086022","cross_references":{"pubmed":["32047114"],"doi":["10.1074/jbc.RA120.012566"]}}