{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Boissier R"],"pubmed_abstract":["<b>Background:</b> Better understanding of the contribution of donor aging and comorbidity factors of expanded criteria donors (ECD) to the clinical outcome of a transplant is a challenge in kidney transplantation. We investigated whether the features of donor-derived stromal vascular fraction of perirenal adipose tissue (PRAT-SVF) could be indicative of the deleterious impact of the ECD microenvironment on a renal transplant. <b>Methods:</b> A comparative analysis of cellular components, transcriptomic and vasculogenic profiles was performed in PRAT-SVF obtained from 22 optimal donors and 31 ECD deceased donors. We then investigated whether these parameters could be associated with donor aging and early allograft dysfunction. <b>Results:</b> When compared with the PRAT-SVF of non-ECD dono"],"journal":["Frontiers in immunology"],"pagination":["445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7089962"],"repository":["biostudies-literature"],"pubmed_title":["Perirenal Adipose Tissue Displays an Age-Dependent Inflammatory Signature Associated With Early Graft Dysfunction of Marginal Kidney Transplants."],"pmcid":["PMC7089962"],"pubmed_authors":["Meunier M","Sabatier F","Simoncini S","Paul P","Arnaud L","Legris T","Karsenty G","Magalon J","Francois P","Dignat George F","Lechevallier E","Gondran Tellier B","Lyonnet L","Giraudo L","Boissier R","Burtey S"],"additional_accession":[]},"is_claimable":false,"name":"Perirenal Adipose Tissue Displays an Age-Dependent Inflammatory Signature Associated With Early Graft Dysfunction of Marginal Kidney Transplants.","description":"<b>Background:</b> Better understanding of the contribution of donor aging and comorbidity factors of expanded criteria donors (ECD) to the clinical outcome of a transplant is a challenge in kidney transplantation. We investigated whether the features of donor-derived stromal vascular fraction of perirenal adipose tissue (PRAT-SVF) could be indicative of the deleterious impact of the ECD microenvironment on a renal transplant. <b>Methods:</b> A comparative analysis of cellular components, transcriptomic and vasculogenic profiles was performed in PRAT-SVF obtained from 22 optimal donors and 31 ECD deceased donors. We then investigated whether these parameters could be associated with donor aging and early allograft dysfunction. <b>Results:</b> When compared with the PRAT-SVF of non-ECD dono","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-05-03T05:57:26.977Z","creation":"2020-05-22T16:33:23Z"},"accession":"S-EPMC7089962","cross_references":{"pubmed":["32256495"],"doi":["10.3389/fimmu.2020.00445"]}}