biostudies-literatureUnknown11Boissier R<b>Background:</b> Better understanding of the contribution of donor aging and comorbidity factors of expanded criteria donors (ECD) to the clinical outcome of a transplant is a challenge in kidney transplantation. We investigated whether the features of donor-derived stromal vascular fraction of perirenal adipose tissue (PRAT-SVF) could be indicative of the deleterious impact of the ECD microenvironment on a renal transplant. <b>Methods:</b> A comparative analysis of cellular components, transcriptomic and vasculogenic profiles was performed in PRAT-SVF obtained from 22 optimal donors and 31 ECD deceased donors. We then investigated whether these parameters could be associated with donor aging and early allograft dysfunction. <b>Results:</b> When compared with the PRAT-SVF of non-ECD donoFrontiers in immunology445https://www.ebi.ac.uk/biostudies/studies/S-EPMC7089962biostudies-literaturePerirenal Adipose Tissue Displays an Age-Dependent Inflammatory Signature Associated With Early Graft Dysfunction of Marginal Kidney Transplants.PMC7089962Meunier MSabatier FSimoncini SPaul PArnaud LLegris TKarsenty GMagalon JFrancois PDignat George FLechevallier EGondran Tellier BLyonnet LGiraudo LBoissier RBurtey SfalsePerirenal Adipose Tissue Displays an Age-Dependent Inflammatory Signature Associated With Early Graft Dysfunction of Marginal Kidney Transplants.<b>Background:</b> Better understanding of the contribution of donor aging and comorbidity factors of expanded criteria donors (ECD) to the clinical outcome of a transplant is a challenge in kidney transplantation. We investigated whether the features of donor-derived stromal vascular fraction of perirenal adipose tissue (PRAT-SVF) could be indicative of the deleterious impact of the ECD microenvironment on a renal transplant. <b>Methods:</b> A comparative analysis of cellular components, transcriptomic and vasculogenic profiles was performed in PRAT-SVF obtained from 22 optimal donors and 31 ECD deceased donors. We then investigated whether these parameters could be associated with donor aging and early allograft dysfunction. <b>Results:</b> When compared with the PRAT-SVF of non-ECD dono2020-01-01T00:00:00Z20202026-05-03T05:57:26.977Z2020-05-22T16:33:23ZS-EPMC70899623225649510.3389/fimmu.2020.00445