{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["77(6)"],"submitter":["Andre C"],"pubmed_abstract":["<h4>Importance</h4>Increasing evidence suggests that sleep-disordered breathing (SDB) increases the risk of developing Alzheimer clinical syndrome. However, the brain mechanisms underlying the link between SDB and Alzheimer disease are still unclear.<h4>Objective</h4>To determine which brain changes are associated with the presence of SDB in older individuals who are cognitively unimpaired, including changes in amyloid deposition, gray matter volume, perfusion, and glucose metabolism.<h4>Design, setting, and participants</h4>This cross-sectional study was conducted using data from the Age-Well randomized clinical trial of the Medit-Ageing European project, acquired between 2016 and 2018 at Cyceron Center in Caen, France. Community-dwelling older adults were assessed for eligibility and wer"],"journal":["JAMA neurology"],"pagination":["716-724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7091393"],"repository":["biostudies-literature"],"pubmed_title":["Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary Analysis of a Randomized Clinical Trial."],"pmcid":["PMC7091393"],"pubmed_authors":["Medit-Ageing Research Group","Ourry V","Marchant NL","Lutz A","Rehel S","Bejanin A","de la Sayette V","Mezenge F","Abbas A","de Flores R","Chetelat G","Landeau B","Collette F","Kuhn E","Sherif S","Bertran F","Rauchs G","Le Du G","Tomadesso C","Arenaza-Urquijo EM","Touron E","Andre C","Delcroix N","Moulinet I","Vivien D","Manrique A","Klimecki OM","Poisnel G"],"additional_accession":[]},"is_claimable":false,"name":"Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary Analysis of a Randomized Clinical Trial.","description":"<h4>Importance</h4>Increasing evidence suggests that sleep-disordered breathing (SDB) increases the risk of developing Alzheimer clinical syndrome. However, the brain mechanisms underlying the link between SDB and Alzheimer disease are still unclear.<h4>Objective</h4>To determine which brain changes are associated with the presence of SDB in older individuals who are cognitively unimpaired, including changes in amyloid deposition, gray matter volume, perfusion, and glucose metabolism.<h4>Design, setting, and participants</h4>This cross-sectional study was conducted using data from the Age-Well randomized clinical trial of the Medit-Ageing European project, acquired between 2016 and 2018 at Cyceron Center in Caen, France. Community-dwelling older adults were assessed for eligibility and wer","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2026-05-01T17:25:48.624Z","creation":"2025-02-19T03:41:13.262Z"},"accession":"S-EPMC7091393","cross_references":{"pubmed":["32202593"],"doi":["10.1001/jamaneurol.2020.0311"]}}