biostudies-literatureUnknown77(6)Andre C<h4>Importance</h4>Increasing evidence suggests that sleep-disordered breathing (SDB) increases the risk of developing Alzheimer clinical syndrome. However, the brain mechanisms underlying the link between SDB and Alzheimer disease are still unclear.<h4>Objective</h4>To determine which brain changes are associated with the presence of SDB in older individuals who are cognitively unimpaired, including changes in amyloid deposition, gray matter volume, perfusion, and glucose metabolism.<h4>Design, setting, and participants</h4>This cross-sectional study was conducted using data from the Age-Well randomized clinical trial of the Medit-Ageing European project, acquired between 2016 and 2018 at Cyceron Center in Caen, France. Community-dwelling older adults were assessed for eligibility and werJAMA neurology716-724https://www.ebi.ac.uk/biostudies/studies/S-EPMC7091393biostudies-literatureAssociation of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary Analysis of a Randomized Clinical Trial.PMC7091393Medit-Ageing Research GroupOurry VMarchant NLLutz ARehel SBejanin Ade la Sayette VMezenge FAbbas Ade Flores RChetelat GLandeau BCollette FKuhn ESherif SBertran FRauchs GLe Du GTomadesso CArenaza-Urquijo EMTouron EAndre CDelcroix NMoulinet IVivien DManrique AKlimecki OMPoisnel GfalseAssociation of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary Analysis of a Randomized Clinical Trial.<h4>Importance</h4>Increasing evidence suggests that sleep-disordered breathing (SDB) increases the risk of developing Alzheimer clinical syndrome. However, the brain mechanisms underlying the link between SDB and Alzheimer disease are still unclear.<h4>Objective</h4>To determine which brain changes are associated with the presence of SDB in older individuals who are cognitively unimpaired, including changes in amyloid deposition, gray matter volume, perfusion, and glucose metabolism.<h4>Design, setting, and participants</h4>This cross-sectional study was conducted using data from the Age-Well randomized clinical trial of the Medit-Ageing European project, acquired between 2016 and 2018 at Cyceron Center in Caen, France. Community-dwelling older adults were assessed for eligibility and wer2020-01-01T00:00:00Z2020 Jun2026-05-01T17:25:48.624Z2025-02-19T03:41:13.262ZS-EPMC70913933220259310.1001/jamaneurol.2020.0311