{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Esposito M"],"funding":["North Atlantic Treaty Organization","Professional Staff Congress-City University of New York","National Science Foundation"],"pagination":["e0230572"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7094851"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(3)"],"pubmed_abstract":["Chromatin structure plays a decisive role in gene regulation through the actions of transcriptional activators, coactivators, and epigenetic machinery. These trans-acting factors contribute to gene expression through their interactions with chromatin structure. In yeast INO1 activation, transcriptional activators and coactivators have been defined through intense study but the mechanistic links within these trans-acting factors and their functional implications are not yet fully understood. In this study, we examined the crosstalk within transcriptional coactivators with regard to the implications of Snf2p acetylation during INO1 activation. Through various biochemical analysis, we demonstrated that both Snf2p and Ino80p chromatin remodelers accumulate at the INO1 promoter in the absence o"],"journal":["PloS one"],"pubmed_title":["Accumulation of unacetylatable Snf2p at the INO1 promoter is detrimental to remodeler recycling supply for CUP1 induction."],"pmcid":["PMC7094851"],"funding_grant_id":["61610-0049","NATO SPS G5266","MCB 0919218"],"pubmed_authors":["Esposito A","Kaluski G","Esposito M","Sherr GL","Shen CH","Ellington F"],"additional_accession":[]},"is_claimable":false,"name":"Accumulation of unacetylatable Snf2p at the INO1 promoter is detrimental to remodeler recycling supply for CUP1 induction.","description":"Chromatin structure plays a decisive role in gene regulation through the actions of transcriptional activators, coactivators, and epigenetic machinery. These trans-acting factors contribute to gene expression through their interactions with chromatin structure. In yeast INO1 activation, transcriptional activators and coactivators have been defined through intense study but the mechanistic links within these trans-acting factors and their functional implications are not yet fully understood. In this study, we examined the crosstalk within transcriptional coactivators with regard to the implications of Snf2p acetylation during INO1 activation. Through various biochemical analysis, we demonstrated that both Snf2p and Ino80p chromatin remodelers accumulate at the INO1 promoter in the absence o","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-06-01T12:26:50.885Z","creation":"2025-06-01T12:26:50.885Z"},"accession":"S-EPMC7094851","cross_references":{"pubmed":["32210477"],"doi":["10.1371/journal.pone.0230572"]}}